Results 121 to 130 of about 6,087 (178)

Modulation of the Gut-Liver Axis and Nrf2/HO-1-Mediated Antioxidant Defense by <i>Styela plicata</i> Extract Against Alcoholic Liver Injury. [PDF]

Antioxidants (Basel)
Li Q, Liu Y, Shan S, Wen Y, Wu X, Xie S, Liu B, Zhao C, Chen W.   +8 more
europepmc   +1 more source

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Lipoxins in inflammation

Clinical Hemorheology and Microcirculation, 2022
Lipoxins and ATL appear to be the first recognized members of a new class of endogenous mediator that are anti-inflammatory or serve for the “pro-resolution” of inflammation. PGE2 can and may display anti-inflammatory properties in certain settings, but in most cases, it enhances inflammation in vivo.
Shivani, Sachdeva, Harish, Saluja, Ameet, Mani, M B, Phadnaik, Shubhangi, Mani   +4 more
openaire   +2 more sources

Conformational analysis of lipoxin A, lipoxin B and their trans-isomers

Lipids and Lipid Metabolism, 1988
Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes. Each compound displays highly stereospecific biological actions. Here, we present a computational description of the following compounds: lipoxin A, (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-
Robert Brasseur, Jean-Marie Ruysschaert, Charles N Serhan   +2 more
exaly   +5 more sources

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

European Journal of Pharmacology, 2015
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) derived by the lipoxygenase (LO) route of arachidonic acid metabolism. In particular, they are formed and released by cells expressing 5-,
ROMANO, Mario, CIANCI, ELEONORA, SIMIELE, FELICE, RECCHIUTI, ANTONIO   +3 more
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Lipoxins and lipoxin analogs in asthma

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The pathobiology of asthma is characterized by production of eicosanoids, a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. Lipoxins (LXs) are products of arachidonic acid metabolism that are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function.
openaire   +2 more sources

Lipoxins and Aspirin-Triggered Lipoxins in Airway Responses

2003
Here, we have demonstrated potent inhibition of allergen-mediated pulmonary inflammation and airway hyper-responsiveness by a novel dual-pronged action of LX's. Moreover, these results indicate that LX's play pivotal and previously unappreciated roles in regulating allergy and pulmonary inflammation.
Bruce D, Levy, George T, De Sanctis, Pallavi R, Devchand, Eugene, Kim, Kate, Ackerman, Birgitta, Schmidt, Wojciech, Szczeklik, Jeffrey M, Drazen, Charles N, Serhan   +8 more
openaire   +2 more sources

Lipoxins: revelations on resolution

Trends in Pharmacological Sciences, 2001
Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered
B, McMahon, S, Mitchell, H R, Brady, C, Godson   +3 more
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Lipoxin analogs and lipoxin formation in vivo

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The definition of lipoxin bioactions in vivo and of lipoxin levels in humans, under physiological and pathological conditions, represents a main task toward the clinical use of lipoxins. The introduction of lipoxin stable analogs and of new methodology for immunological measurements of lipoxin A4 in human fluids is significantly contributing to fulfill
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Synthesis of lipoxin b

Tetrahedron Letters, 1986
The synthesis of four isomers of 5.14,15-triHETE is reported. The key step is the coupling of acetylene 11 (or 19) with epoxide 7 to afford alcohol 12 (or 20). Natural lipoxin B is found to correspond to a mixture of 14R-8-cis-1, 14R-8-trans-3 and 14S-8-trans-4.
J, Morris, D G, Wishka
openaire   +2 more sources