Results 131 to 140 of about 6,087 (178)
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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Angiogenesis, the growth of new capillaries from pre-existing ones, occurs through dynamic functions of the endothelial cells (EC), including migration, proliferation and maturation, which are essential to achieve an organized formation of the vessel sprout.
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The lipoxins: Determination of their biosynthesis
Pharmacological Research Communications, 1986The stereochemistry and double bond geometry of a novel series of leukocyte derived arachidonic acid metabolites, the lipoxins, was determined by comparison to pure unambiguous synthetic standards. The lipoxins were found to be a mixture of four lipoxin A isomers and two lipoxin B isomers.
J, Rokach +4 more
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Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Dysregulated neutrophilic inflammation and chronic infection lead to progressive destruction of the airways in cystic fibrosis (CF). Despite considerable recent progress in therapy, the median survival of patients with CF remains around 30 years. The lipoxins are endogenous anti-inflammatory lipid mediators that are important regulators of neutrophilic
Christopher L, Karp +4 more
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Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005Lipoxin A4 (LXA4) and aspirin-triggered 15-epi-LXA4 (ATL) are emerging as endogenous braking signals for neutrophil-mediated tissue injury. LXA4 and ATL and their metabolically stable analogues display potent inhibitory actions in human isolated cells and blood, including attenuation of expression of adhesion molecules on leukocytes and endothelial ...
János G, Filep +2 more
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The effects of lipoxin A and lipoxin B on functional responses of human granulocytes
Biochemical and Biophysical Research Communications, 1987Lipoxin A and lipoxin B (LXA and LXB) are formed from arachidonic acid by leukocyte 5- and 15-lipoxygenases. We have assessed the effects of synthetic lipoxins on functional responses of human granulocytes. LXA stimulated migration at 1 nM. The effect was highly stereospecific, since e.g. 6S-LXA and LXB were less active than LXA.
J, Palmblad +5 more
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Lipid Mediators: Lipoxin and Aspirin-Triggered 15-Epi-Lipoxins
Inflammation & Allergy-Drug Targets, 2006Lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) are emerging as major promoters of resolution of the inflammatory reaction. These eicosanoids, that carry a tetraene chromophore, derive from sequential lipoxygenase (LO) metabolism of arachidonic acid. Three principal routes of LX/ATL biosynthesis have been uncovered.
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The Lipoxins: Synthesis and Biosynthesis
1988Since the first report of their isolation in 19841,2 the lipoxins have generated considerable interest amongst researchers studying the lipoxygenase pathway. The interest has been due both to the novel structure and intreging pharmacological properties3,4,5 reported for these bio-molecules.
B, Fitzsimmons, J, Rokach
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Anti-inflammatory circuitry: Lipoxin, aspirin-triggered lipoxins and their receptor ALX
Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005Endogenous chemical mediators or autacoids play key roles in controlling inflammation and its programmed resolution. Among them, it is known that lipoxins (LX) and aspirin-triggered LX (ATL) evoke bioactions in a range of physiologic and pathophysiologic processes and serve as endogenous lipid/chemical mediators that stop neutrophilic infiltration and ...
Nan, Chiang +2 more
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Total synthesis of lipoxin A4 and lipoxin B4 from butadiene
Tetrahedron Letters, 2000The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids.
Rodriguez, A +4 more
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The Glomerular Physiology of Lipoxin-A
1988A number of renal diseases, such as acute and chronic glomerulonephritis, acute interstitial nephritis, allograft rejection, and others are characterized by the presence inflammatory cellular infiltrates consisting, at various stages, of neutrophils, macrophages, monocytes, eosinophils, and lymphocytes.
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