Results 31 to 40 of about 11,031 (247)
Immunomodulation of periodontitis with SPMs
Frontiers in Oral Health, 2023 Inflammation is a critical component in the pathophysiology of numerous disease processes, with most therapeutic modalities focusing on its inhibition in order to achieve treatment outcomes.
Vaibhav Sahni +2 more
doaj +1 more source
Outlining eicosanoid biosynthesis in the crustacean [PDF]
, 2008 Background Eicosanoids are biologically active, oxygenated metabolites of three C20 polyunsaturated fatty acids. They act as signalling molecules within the autocrine or paracrine system in both vertebrates and invertebrates mainly functioning as ...
Callaghan Amanda +3 more
core +3 more sources
Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair
Frontiers in Immunology, 2022 ObjectiveResidual scarring after cleft lip repair surgery remains a challenge for both surgeons and patients and novel therapeutics are critically needed. The objective of this preclinical experimental study was to evaluate the impact of the methyl-ester
Evangelos Papathanasiou +11 more
doaj +1 more source
Neuroinflammation is a putative target for the prevention and treatment of perioperative neurocognitive disorders. [PDF]
, 2019 IntroductionThe demographics of aging of the surgical population has increased the risk for perioperative neurocognitive disorders in which trauma-induced neuroinflammation plays a pivotal role.Sources of dataAfter determining the scope of the review ...
Lai, IK, Li, R, Maze, M, Saxena, S
core +2 more sources
Frontiers in Immunology, 2020 G-protein-coupled receptor 40 (GPR40) is known to play a role in the regulation of fatty acids, insulin secretion, and inflammation. However, the function of this receptor in human neutrophils, one of the first leukocytes to arrive at the site of ...
Patricia R. Souza +8 more
doaj +1 more source
Lipoxins in the Nervous System: Brighter Prospects for Neuroprotection
Frontiers in Pharmacology, 2022 Lipoxins (LXs) are generated from arachidonic acid and are involved in the resolution of inflammation and confer protection in a variety of pathological processes.
Jiayu Zhang +4 more
doaj +1 more source
Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators [PDF]
, 2013 The role of non-steroidal anti-inflammatory drugs in inflammatory bowel disease is controversial, as they have been implicated in disease aggravation. Different from other cyclooxygenase inhibitors, acetylsalicylic acid (ASA) enhances the formation of ...
Baumgart, Daniel C. +7 more
core +3 more sources
Frontiers in Immunology, 2020 Eicosanoids modulate both innate and adaptive immune responses in Mycobacterium tuberculosis (Mtb) infection and have been suggested as possible Host Directed Therapy (HDT) targets, but more knowledge of eicosanoid dynamics in Mtb infection is required ...
Kristin Grotle Nore +7 more
doaj +1 more source
Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021 Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Darrell, Andrews, Catherine, Godson
openaire +2 more sources
Resolution-Based Therapies: The Potential of Lipoxins to Treat Human Diseases
Frontiers in Immunology, 2021 Inflammation is an a physiological response instead an essential response of the organism to injury and its adequate resolution is essential to restore homeostasis.
Rafael I. Jaén +9 more
doaj +1 more source