Results 61 to 70 of about 11,031 (247)

Lipoxin receptor agonist and inhibition of LTA4 hydrolase prevent tight junction disruption caused by P. aeruginosa filtrate in airway epithelial cells.

PLoS ONE, 2023
Airway diseases can disrupt tight junction proteins, compromising the epithelial barrier and making it more permeable to pathogens. In people with pulmonary disease who are prone to infection with Pseudomonas aeruginosa, pro-inflammatory leukotrienes are
Kameljit K Kalsi, Sonya Jackson, Deborah L Baines   +2 more
doaj   +1 more source

Modulation of Cox-1, 5-, 12- and 15-Lox by popular herbal remedies used in southern Italy against psoriasis and other skin diseases. [PDF]

, 2014
Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids.
Amenta, Ammon, Bader, Brand-Williams, Bremner, Bruni, Bruno, Charlier, Dehmlow, DiSepio, Flora, Glaser, Henke, Iversen, Luper, Mosmann, Pannala, Safayhi, Safayhi, Serhan, Spector, Sun, Tornhamre, Tzakou, Voorhees, Wang, Yamamoto   +26 more
core   +1 more source

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source

Expression regulation of MAO isoforms in monocytic cells in response to Th2 cytokines [PDF]

, 2005
Background: Th2-cytokines, such as interleukins-4 and –13 (IL-4, IL-13), have been identified as alternative stimuli of monocytes/macrophages. We have recently profiled the gene-expression pattern of IL-4-teated human peripheral monocytes and found that ...
Billett, E, Chaitidis, P, Kuban, RJ, Kuhn, H, Ungethuem, U   +4 more
core  

Resolution of inflammation: a new therapeutic frontier [PDF]

, 2016
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
A Ariel, A Ariel, A Basran, A Boasso, A Chatterjee, A Devitt, A Kovalenko, A Recchiuti, A Recchiuti, A Rossi, AB Shyu, AE Leitch, AE Leitch, AG Rossi, AG Rossi, AG Rossi, AG Rossi, AI Medeiros, AJ Degraaf, AJ O'Brien, AL Alessandri, AL Alessandri, AL Robertson, AP Cope, AW Segal, B Amulic, B Bondue, B Geering, B Gemici, B Leon, BA Zabel, BJ Evans, C Favas, C Godson, C Qin, C Schauer, C von Roretz, C Yao, CA Wijbrandts, CC Mihalache, CD Buckley, CD Buckley, CD Gregory, CE Clay, CH Fong, CN Serhan, CN Serhan, CN Serhan, CW Yang, D Bhaumik, D El Kebir, D Park, DA Isenberg, DA Sawatzky, DC Cara, Derek W. Gilroy, DH Rodrigues, DR Gude, DS Straus, DW Gilroy, DW Gilroy, DW Gilroy, E Carballo, E Carballo, E Perdiguero, E Tili, EB Wilson, EE McGrath, EL Hahn, ES Mocarski, EY Chung, F Mariani, FJ Sheedy, FK Chan, FK Swirski, FM Menzies, FN Gavins, FS Machado, G D'Agostino, G Fredman, G Song, G Stoecklin, GA Rabinovich, GJ Bellingan, GJ Graham, GJ Graham, GL Bannenberg, H Braley-Mullen, H Muhl, H Nakano, H Seki, HJ Anders, HT Chung, I Allaeys, I McConnell, I Mitroulis, I Mitroulis, I Sauer, IK Poon, J Bystrom, J Bystrom, J Bystrom, J Gong, J Hopkins, J Liang, J Liu, J Liu, J Newson, J Savill, J Savill, J Seok, James N. Fullerton, JD Langereis, JD Pollock, JL Cash, JL Wallace, JM Gonzalez-Navajas, JM Schwab, JP Vago, JR Brown, JR Teijaro, JW Zmijewski, K Ersland, K Horino, K Lauber, K Linker, K Matsushita, K Miles, K Phillips, K Sasaki, K Takao, K Uchida, K Vyas, KD Taganov, KE Blume, KH Weylandt, KP High, L Arnold, L Chen, L Li, L Sun, LJ Harvey, LM Wakim, LP Sousa, LP Sousa, LR Prince, LS van Rijt, M Back, M Brittan, M Drechsler, M Feoktistova, M Kool, M Lagarde, M Mavers, M Perretti, M Perretti, M Piecyk, M Romano, M Romano, M Rosas, M Singh, M Vukmanovic-Stejic, MA Nahid, MC Martin, MF Schmidt, MG Johnston, MM Chan, MM Matzelle, MM Perry, MR Elliott, MR Jones, MR Junttila, MS Bynoe, MS Chapman, MT Elola, N Chiang, N Chiang, N Dufton, NC Henderson, NM Reddy, P Anderson, P Anderson, P Libby, P Ramachandran, P Sampath, PA Insel, Q Remijsen, R Gyurko, R Mounier, R Mukhopadhyay, R Pettipher, R Rajakariar, R Rajakariar, R Tomasini, RJ Nibbs, RL Ogilvie, RL Ogilvie, RM Day, RM Dores, RM Thurlings, RN Cahill, S Bala, S Brown, S Divanovic, S Krishnamoorthy, S Mi, S Parathath, S Schif-Zuck, S Uderhardt, S Yazid, S Yona, SB Berger, SG Trivedi, SJ Gardai, SJ Nicholls, SW Jones, SW Ryter, T Brzoska, T Hisada, T Lawrence, T Montero-Melendez, T Shay, T Vanden Berghe, U Koedel, UE Knies, V Deretic, VA Fadok, VA Fadok, VA Fadok, VA Fadok, VA Fadok, W Jenner, WH Shao, WJ Kim, WR Hansen, Y Fang, Y Fang, Y Okabe, Y Uehara, YL Chen   +239 more
core   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Lipoxins: nature's way to resolve inflammation

Journal of Inflammation Research, 2015
Jayashree A Chandrasekharan, Neelam Sharma-Walia HM Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USAAbstract: An effective ...
Chandrasekharan JA, Sharma-Walia N
doaj  

Expression of mRNA for phospholipase A(2), cyclooxygenases, and lipoxygenases in cultured human umbilical vascular endothelial and smooth muscle cells and in biopsies from umbilical arteries and veins [PDF]

, 1998
Arachidonic acid (AA) is released by phospholipase A(2) (PLA(2)) and then converted into vasoactive and inflammatory eicosanoids by cyclooxygenases (COX) and lipoxygenases (LOX).
Carlsson, Maria, Gidlöf, Anders, Sirsjö, Allan, Söderkvist, Peter, Uhl, Eberhard, Öst, Martin   +5 more
core   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

EICOSANOIDS AND INFLAMMATION

Современная ревматология, 2016
Inflammation is the most important element in the pathogenesis of major human diseases. It determines the fundamental value of anti-inflammatory therapy in the modern concept of targeted pathogenetic treatment.
A. E. Karateev, T. L. Aleinikova
doaj   +1 more source