Results 71 to 80 of about 261 (130)

Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins

Brazilian Journal of Medical and Biological Research, 2001
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a ...
Fierro I.M., Serhan C.N.
doaj  

Advances in the Chemistry and Biology of Specialised Pro-Resolving Mediators (SPMs)

Molecules
This review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM ...
Lucy Byrne, Patrick J. Guiry
doaj   +1 more source

Utilization of lipoxins and other specialised pro-resolving mediators in the prevention and treatment of diabetic nephropathy and diabetic cardiovascular disease

Acta Marisiensis - Seria Medica
Diabetes mellitus type 2 is a chronic disease caused by insulin resistance. Whilst first originating in the adipose tissue, this pathophysiological process later affects the muscles and the liver as well.
Bergo Ivan, Pastorello Ylenia
doaj   +1 more source

Lipoxins A4 and B4 inhibit glial cell activation via CXCR3 signaling in acute retinal neuroinflammation

Journal of Neuroinflammation
Lipoxins are small lipids that are potent endogenous mediators of systemic inflammation resolution in a variety of diseases. We previously reported that Lipoxins A4 and B4 (LXA4 and LXB4) have protective activities against neurodegenerative injury.
Izhar Livne-Bar, Shubham Maurya, Karsten Gronert, Jeremy M. Sivak   +3 more
doaj   +1 more source

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Lipoxins in inflammation

Clinical Hemorheology and Microcirculation, 2022
Lipoxins and ATL appear to be the first recognized members of a new class of endogenous mediator that are anti-inflammatory or serve for the “pro-resolution” of inflammation. PGE2 can and may display anti-inflammatory properties in certain settings, but in most cases, it enhances inflammation in vivo.
Shivani, Sachdeva, Harish, Saluja, Ameet, Mani, M B, Phadnaik, Shubhangi, Mani   +4 more
openaire   +2 more sources

Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021
Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics.
Catherine Godson
exaly   +3 more sources

Lipoxins: revelations on resolution

Trends in Pharmacological Sciences, 2001
Lipoxins (LXs) are endogenously produced eicosanoids typically generated during cell-cell interactions. In this article, the compelling evidence from in vitro and in vivo model systems that LXs actively promote the resolution of inflammation is reviewed. Of particular interest are indications that stable synthetic analogues of LXs and aspirin-triggered
Catherine Godson, Blaithin Mcmahon, C Godson   +2 more
exaly   +3 more sources

Lipoxins and aspirin-triggered lipoxins in resolution of inflammation

European Journal of Pharmacology, 2015
The resolution of the inflammatory response is highly regulated by the timely biosynthesis of a number of endogenous lipid mediators. Among these, lipoxins (LX) and their 15-epimers, aspirin triggered lipoxins (ATL) derived by the lipoxygenase (LO) route of arachidonic acid metabolism. In particular, they are formed and released by cells expressing 5-,
ROMANO, Mario, CIANCI, ELEONORA, SIMIELE, FELICE, RECCHIUTI, ANTONIO   +3 more
openaire   +3 more sources

Lipoxins and lipoxin analogs in asthma

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The pathobiology of asthma is characterized by production of eicosanoids, a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. Lipoxins (LXs) are products of arachidonic acid metabolism that are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function.
openaire   +2 more sources

Conformational analysis of lipoxin A, lipoxin B and their trans-isomers

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988
Lipoxin A and lipoxin B (LXA and LXB) are formed from the oxygenation of arachidonic acid by interactions between the 5- and 15-lipoxygenases of human leukocytes. Each compound displays highly stereospecific biological actions. Here, we present a computational description of the following compounds: lipoxin A, (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-
Brasseur, Robert, Deleers, Michel, Ruysschaert, Jean Marie, Samuelsson, Bengt, Serhan, Charles N   +4 more
openaire   +4 more sources