12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li +13 more
wiley +1 more source
Genome-wide identification reveals unprecedented expansion and stress-responsive expression patterns of the lipoxygenase gene family in soybean (<i>Glycine max</i> L.). [PDF]
Lamlom SF +5 more
europepmc +1 more source
Abstract INTRODUCTION Alzheimer's disease (AD) study participants may present with cognitive impairment who do not have brain amyloid deposits (Aβ−). Identifying predictive biomarkers for non‐amyloid‐related CI may provide better screening tests for trials seeking only CI Aβ+ participants and new therapy targets.
Richard C. Mohs +11 more
wiley +1 more source
Correction to "Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis". [PDF]
europepmc +1 more source
Comparative Analysis of Proximate, Nutritional, and Phytochemical Profiles of Soybean Varieties Using FTIR and HPLC. [PDF]
Fayyaz MS +6 more
europepmc +1 more source
Failure of the inhibition of rat gastric mucosal 5‐lipoxygenase by novel acetohydroxamic acids to prevent ethanol‐induced damage [PDF]
N. K. Boughton-Smith +1 more
openalex +1 more source
Evaluation of ASC as a therapeutic target for Alzheimer's disease
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton +12 more
wiley +1 more source
Erratum: Towards Precision Treatment of Chronic Obstructive Pulmonary Disease Exacerbations: The Role of Specialized Proresolving Mediators. [PDF]
europepmc +1 more source

