Results 201 to 210 of about 43,549 (263)

Anthocyanins as lipoxygenase inhibitors

Molecular Nutrition & Food Research, 2009
AbstractHealth benefits associated with diets rich in anthocyanins are ascribed to multilevel biological activities including antioxidative and anti‐inflammatory effects. The present study addresses lipoxygenase inhibition as a mechanism by which anthocyanins may exert health promoting effects. The inhibitory potential of delphinidin (Dp), cyanidin (Cy)
Bastian, Knaup, Anett, Oehme, Anagnostis, Valotis, Peter, Schreier   +3 more
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Silymarin, an inhibitor of lipoxygenase

Experientia, 1979
Silybin (I), silydianin (II) and silychristin (III), the constituents of silymarin, non-competitively inhibit the lipoxygenase from soybeans (EC 1.13.11.12) in vitro.
F, Fiebrich, H, Koch
openaire   +2 more sources

New Bis-catechols 5-lipoxygenase inhibitors

Bioorganic & Medicinal Chemistry, 2001
Three polyhydroxy-2-phenylnaphthalenes (1-3) and the oxy analogue of tetrahydroxypavinan (4) were prepared and evaluated for their antioxidant properties (inhibition of diphenylpycrylhydrazyl radical (DPPH), reduction of iron (III) ion) and inhibition of 5-lipoxygenase (5-LO) activity. Their three-dimensional structures were established on the basis of
Dupont, R., Goossens, J.F., Cotelle, N., Vrielynck, L., Vezin, H., Henichart, J.P., Cotelle, P.   +6 more
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Episulfide inhibitors of lipoxygenase

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract A set of epoxide and episulfide substrate mimics were synthesized as inhibitors of soybean lipoxygenase. Enzyme inhibition was observed exclusively with the 12,13-episulfides (1a and 4a), with a high degree of regio- and chemoselectivity. Inhibition by 1a was shown to occur with reduction of the enzyme active site iron from the catalytically
Stephen W. Wright, Mark J. Nelson
openaire   +1 more source

Hydroxamic acid inhibitors of 5-lipoxygenase

Journal of Medicinal Chemistry, 1987
The hydroxamic acid functionality can be incorporated in a variety of simple molecules to produce potent inhibitors of 5-lipoxygenase. As an example of this, the structure-activity relationships in a series of omega-phenylalkyl and omega-naphthylalkyl hydroxamic acids are presented. Among the features described are the influence of hydrophobicity, aryl
J B, Summers, H, Mazdiyasni, J H, Holms, J D, Ratajczyk, R D, Dyer, G W, Carter   +5 more
openaire   +2 more sources

15-Lipoxygenase inhibitors: a patent review

Expert Opinion on Therapeutic Patents, 2015
15-Lipoxygenases (15-LOXes) are a family of iron-containing proteins that have the capability for unsaturated fatty acid peroxidation in animals and plants. Two types of the enzyme, 15-LOX-1 and 15-LOX-2, have been recognized in mammals to have different abilities in the peroxidation of arachidonic acid and linoleic acid.
Hamid, Sadeghian, Atena, Jabbari
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4-Hydroxythiazole inhibitors of 5-lipoxygenase

Journal of Medicinal Chemistry, 1991
4-Hydroxythiazoles have been identified as potent inhibitors of 5-lipoxygenase in vitro exhibiting IC50's of less than 1 microM. An investigation of structure-activity relationships showed that the most potent inhibitors of this series are the 5-phenyl derivatives. The corresponding thiazolidin-4-one analogues were found to be relatively inactive.
F A, Kerdesky, J H, Holms, J L, Moore, R L, Bell, R D, Dyer, G W, Carter, D W, Brooks   +6 more
openaire   +2 more sources