Results 11 to 20 of about 6,058 (200)

HIV-1 Tat interacts with LIS1 protein [PDF]

Retrovirology, 2005
Background HIV-1 Tat activates transcription of HIV-1 viral genes by inducing phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAPII).
Turner Willie, Lane William S, Voloshin Yaroslav, Sapir Tamar, Ammosova Tatyana, Epie Nicolas, Reiner Orly, Nekhai Sergei   +7 more
doaj   +3 more sources

Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein [PDF]

Cell, 2017
SummaryRegulation is central to the functional versatility of cytoplasmic dynein, a motor involved in intracellular transport, cell division, and neurodevelopment. Previous work established that Lis1, a conserved and ubiquitous regulator of dynein, binds to its motor domain and induces a tight microtubule-binding state in dynein.
Morgan E. DeSantis, Michael A. Cianfrocco, Zaw Min Htet, Phuoc Tien Tran, Samara L. Reck‐Peterson, Andrés E. Leschziner   +5 more
  +8 more sources

Lis1 regulates dynein by sterically blocking its mechanochemical cycle

eLife, 2014
Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development.
Katerina Toropova, Sirui Zou, Anthony J Roberts, William B Redwine, Brian S Goodman, Samara L Reck-Peterson, Andres E Leschziner   +6 more
doaj   +3 more sources

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

Nature Communications, 2016
Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on ...
Dail Chapman, Richard B Vallee
exaly   +2 more sources

LIS1 Missense Mutations [PDF]

Journal of Biological Chemistry, 2003
Michal Caspi, Frédéric M. Coquelle, Cynthia Koifman, Talia Levy, Hiroyuki Arai, Junken Aoki, Jan R. De Mey, Orly Reiner   +7 more
openalex   +3 more sources

En rolig sommervakt som LIS1-lege [PDF]

Tidsskrift for Den norske legeforening
Helena Heimer Rognstad
openalex   +2 more sources

LIS1, CLIP-170's Key to the Dynein/Dynactin Pathway

Molecular and Cellular Biology, 2002
Casper C Hoogenraad, Anna S Akhmanova, Niels Galjart   +2 more
exaly   +2 more sources

LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons

Frontiers in Molecular Neuroscience, 2022
Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith   +3 more
doaj   +1 more source

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

Nature Communications, 2023
Lissencephaly-1 (LIS1) is associated with neurodevelopmental diseases and is known to regulate the molecular motor cytoplasmic dynein activity. Here we show that LIS1 is essential for the viability of mouse embryonic stem cells (mESCs), and it governs ...
Aditya Kshirsagar, Svetlana Maslov Doroshev, Anna Gorelik, Tsviya Olender, Tamar Sapir, Daisuke Tsuboi, Irit Rosenhek-Goldian, Sergey Malitsky, Maxim Itkin, Amir Argoetti, Yael Mandel-Gutfreund, Sidney R. Cohen, Jacob H. Hanna, Igor Ulitsky, Kozo Kaibuchi, Orly Reiner   +15 more
doaj   +1 more source

Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

eLife, 2023
The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer, Morgan E DeSantis, Samara L Reck-Peterson, Andres E Leschziner   +3 more
doaj   +1 more source