Results 21 to 30 of about 6,058 (200)

Two microtubule-plus-end binding proteins LIS1-1 and LIS1-2, homologues of human LIS1 in Neurospora crassa [PDF]

Fungal Genetics and Biology, 2015
LIS1 is a microtubule (Mt) plus-end binding protein that interacts with the dynein/dynactin complex. In humans, LIS1 is required for proper nuclear and organelle migration during cell growth. Although gene duplication is absent from Neurospora crassa, we found two paralogues of human LIS1.
Callejas-Negrete, Olga A, Plamann, Michael, Schnittker, Robert, Bartnicki-García, Salomon, Roberson, Robert W, Pimienta, Genaro, Mouriño-Pérez, Rosa R   +6 more
openaire   +4 more sources

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]

, 2020
Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan, Andrew D. McAinsh, Auckland, Bancroft, Baumbach, Berto, Berto, Bolhy, Bomont, Chan, Ciossani, Currie, DeSantis, Dix, Dudka, Emanuele Roscioli, Etemad, Faulkner, Feng, Filges, Gama, Gassmann, Gutierrez, Haley, Helena Louise Elvidge Coker, Helgeson, Hoffman, Holt, Howell, Huang, Huis In ’t Veld, Johnson, Kanfer, Kanfer, Klinman, Kuhn, Liu, Magidson, Magidson, Maiato, McEwen, McEwen, McKinley, Meraldi, Monda, Moughamian, Musacchio, Musacchio, Musinipally, Olenick, Olziersky, Pandey, Pereira, Peterka, Philip Auckland, Raaijmakers, Ran, Rattner, Rodriguez-Rodriguez, Roscioli, Sacristan, Samejima, Schmidt, Shao, Shrestha, Siller, Simões, Stehman, Tai, Thrower, Toropova, Vagnoni, Vergnolle, Volkov, Wojcik, Wynne, Wynne, Wynne, Yang, Yi, Zhu   +80 more
core   +1 more source

Intracellular Logistics Coordinated by LIS1 and Lissencephaly

Seibutsu Butsuri, 2011
Masami Yamada
openalex   +3 more sources

LIS1—no more no less [PDF]

Molecular Psychiatry, 2002
LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the
O, Reiner, A, Cahana, T, Escamez, S, Martinez   +3 more
openaire   +2 more sources

LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex [PDF]

Human Molecular Genetics, 2013
Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially ...
Moon, Hyang Mi, Youn, Yong Ha, Pemble, Hayley, Yingling, Jessica, Wittmann, Torsten, Wynshaw-Boris, Anthony   +5 more
openaire   +4 more sources

Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts

Developmental Biology, 2008
Chris Q Doe
exaly   +2 more sources

Interneuron Heterotopia in the Lis1 Mutant Mouse Cortex Underlies a Structural and Functional Schizophrenia-Like Phenotype

Frontiers in Cell and Developmental Biology, 2021
LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development.
Raquel Garcia-Lopez, Ana Pombero, Alicia Estirado, Emilio Geijo-Barrientos, Salvador Martinez, Salvador Martinez   +5 more
doaj   +1 more source

CNV and nervous system diseases - what's new? [PDF]

, 2008
Several new genomic disorders caused by copy number variation (CNV) of genes whose dosage is critical for the physiological function of the nervous system have been recently identified.
Gu, W., Lupski, J. R.
core   +3 more sources

LIS1 Clamps Dynein to the Microtubule [PDF]

Cell, 2012
Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic
Trokter, Martina, Surrey, Thomas
openaire   +2 more sources

Inhibition of PP2A by LIS1 increases HIV-1 gene expression

Retrovirology, 2006
Background Lissencephaly is a severe brain malformation in part caused by mutations in the LIS1 gene. LIS1 interacts with microtubule-associated proteins, and enhances transport of microtubule fragments.
Turner Willie, Ammosova Tatyana, Epie Nicolas, Nekhai Sergei   +3 more
doaj   +1 more source