LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma [PDF]
Cancer Cell InternationalBackground Long non-coding RNAs (lncRNAs) are key regulators of the 6-methyladenosine (m6A) epigenetic modification, playing a role in the initiation and progression of tumors.
Meiting Rong +8 more
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Binding of microtubule-associated protein 1B to LIS1 affects the interaction between dynein and LIS1 [PDF]
Biochemical Journal, 2005 For neuronal migration to occur, the cell must undergo morphological changes that require modifications of the cytoskeleton. Several different MAPs (microtubule-associated proteins) or actin-binding proteins are proposed to be involved in the migration of neurons. Therefore we have specifically analysed how two members of the MAP family, MAP1B and LIS1
Eva M. Jiménez‐Mateos +4 more
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A de novo microdeletion involving PAFAH1B (LIS1) related to lissencephaly phenotype
Data in Brief, 2015 Lissencephaly is a type of the congenital malformation of the brain. Due to the impairments of neuronal migration, patients show absence of brain convolution manifesting smooth brain surfaces.
Keiko Shimojima +2 more
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Total callosotomy ameliorates epileptic activity and improves cognitive function in a patient with Miller-Dieker syndrome [PDF]
Epilepsy & Behavior ReportsMiller-Dieker syndrome (MDS) is characterized by facial abnormalities and lissencephaly and is caused by a microdeletion in the region containing the LIS1 gene at chromosome 17p13.3.
Masataka Fukuoka +9 more
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NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 [PDF]
Proceedings of the National Academy of Sciences, 2010 The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like ...
Yuehong Yang +5 more
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Lis1 Regulates Dynein as a Molecular Wedge [PDF]
Biophysical Journal, 2014 Cytoplasmic dynein walks along microtubules by coupling cycles of ATP hydrolysis in its motor domain with cycles of microtubule binding and release at its microtubule-binding domain. Unlike the other cytoskeletal motors--kinesin and myosin--that have achieved functional diversity through molecular diversity, a single isoform of cytoplasmic dynein is ...
Sirui Zou +4 more
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LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein
EMBO Journal, 2008 Masami Yamada +2 more
exaly +3 more sources
Rab6a releases LIS1 from a dynein idling complex and activates dynein for retrograde movement [PDF]
Nature Communications, 2013 Masami Yamada +2 more
exaly +2 more sources
LIS1 and dynein motor function in neuronal migration and development [PDF]
Genes & Development, 2001 Neuronal migration has been studied extensively for over 30 years in diverse mammalian species from the mouse to human. The sequence of events that occurs during cortical development is shared by all of these species (for reviews, see Gleeson and Walsh 2000; Walsh and Goffinet 2000).
Anthony Wynshaw‐Boris +1 more
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