Results 31 to 40 of about 8,390 (226)
LIS1 and NDEL1 Regulate Axonal Trafficking of Mitochondria in Mature Neurons
Frontiers in Molecular Neuroscience, 2022 Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein).
Jai P. Pandey +3 more
doaj +1 more source
Molecular Psychiatry, 2002 LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the
Reiner, Orly +3 more
openaire +3 more sources
Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]
Proceedings of the National Academy of Sciences, 2001 Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique ...
Cahana, Aviv +11 more
openaire +5 more sources
Two microtubule-plus-end binding proteins LIS1-1 and LIS1-2, homologues of human LIS1 in Neurospora crassa [PDF]
Fungal Genetics and Biology, 2015 LIS1 is a microtubule (Mt) plus-end binding protein that interacts with the dynein/dynactin complex. In humans, LIS1 is required for proper nuclear and organelle migration during cell growth. Although gene duplication is absent from Neurospora crassa, we found two paralogues of human LIS1.
Callejas-Negrete, Olga A +6 more
openaire +5 more sources
CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]
, 2020 Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan +80 more
core +1 more source
LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex [PDF]
Human Molecular Genetics, 2013 Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially ...
Moon, Hyang Mi +5 more
openaire +5 more sources
LIS1 Clamps Dynein to the Microtubule [PDF]
Cell, 2012 Cytoplasmic dynein is a motor essential for numerous mechanical processes in eukaryotic cells. How its activity is regulated is largely unknown. By using a combination of approaches including single-molecule biophysics and electron microscopy, Huang et al. in this issue uncover the regulatory mechanism by which LIS1 controls the activity of cytoplasmic
Thomas Surrey, Martina Trokter
openaire +3 more sources
Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1
Scientific Reports, 2022 Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human diseases.
Stanislav Kholmanskikh +2 more
doaj +1 more source
A role for cytoplasmic dynein and LIS1 in directed cell movement [PDF]
The Journal of Cell Biology, 2003 Cytoplasmic dynein has been implicated in numerous aspects of intracellular movement. We recently found dynein inhibitors to interfere with the reorientation of the microtubule cytoskeleton during healing of wounded NIH3T3 cell monolayers. We now find that dynein and its regulators dynactin and LIS1 localize to the leading cell cortex during this ...
Denis Dujardin +5 more
openalex +4 more sources