Results 31 to 40 of about 1,097,318 (312)
Melatonin inhibits bile acids-initiated Cxcl2 expression through JNK/c-Jun signalling pathway
Di-san junyi daxue xuebao, 2022 Objective To investigate the underlying molecular mechanism by which melatonin suppresses bile acids (BAs)-initiated expression of chemokine C-X-C motif chemokine ligand 2 (Cxcl2). Methods Mice were fed a 1% cholic acid (CA)-supplemented diet for 2 weeks
TAN Ya +5 more
doaj +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Acta Medica Iranica, 2022 There is insufficient data about esophageal body dysmotility in patients with refractory gastroesophageal reflux disease (RGERD) who have inadequate response to proton pump inhibitors (PPIs) treatment.
Asghar Bagherzadeh +3 more
doaj
Annals of Hepatology, 2017 Background & Aim. Transarterial chemoembolization (TACE) or sorafenib is recommended for hepatocellular carcinoma BCLC stages B and C respectively. We studied the role of combination of TACE and sorafenib in BCLC stages B/C.Material and methods.
Joy Varghese +9 more
doaj +1 more source
Severe combined immunodeficiency: improved survival leading to detection of underlying liver disease
BMC Gastroenterology, 2023 Background Adenosine deaminase deficiency (ADA) is an autosomal recessive disorder leading to severe combined immunodeficiency (SCID). It is characterized patho-physiologically by intracellular accumulation of toxic products affecting lymphocytes.
Anusha Vittal +9 more
doaj +1 more source
Lipoproteins in Liver Disease [PDF]
Clinical Chemistry and Laboratory Medicine, 1987 Liver disease is associated with profound and characteristic changes in lipoprotein composition and metabolism. The most pronounced alterations are the formation of lipoprotein-X in intra- and extrahepatic cholestasis, the decrease of apolipoproteins A-I and A-II and the increase of apolipoprotein E.
openaire +4 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
BMC Public Health, 2023 Background Alcohol related liver disease (ARLD) is one of the major chronic liver diseases worldwide. This review aimed to describe the global prevalence, incidence, and outcomes of ARLD.
Xuanxuan Niu +7 more
doaj +1 more source
Effect of Statins on Helicobacter pylori Eradication Rate: A Systematic Review and Meta-Analysis
GE: Portuguese Journal of Gastroenterology, 2021 Statins have been used as adjuvants to standard treatment in order to increase the eradication ratesof Helicobacter pylori infection. This study aimed to summarize the results of the efficacy of adding statins to standard treatments used for the ...
Mohsen Rajabnia +7 more
doaj +1 more source