Results 121 to 130 of about 26,671 (292)

Purpose‐Adaptable Reinforced 3D Hyaluronic‐Acid Based Platform to Study Pathomechanisms of the Central Nervous System

Advanced Healthcare Materials, EarlyView.
Platform system to create biofabricated 3D spinal cord tissue models: Combining high resolution PCL fiber placement, a customized, hyaluronic acid‐based hydrogel, two cell types (spinal cord neurons and astrocytes) together with three distinct laminin isoforms allow the formation of functional cell–cell network interactions.
Nicoletta Murenu, Esra Tuerker, Anna‐Lena Wiessler, Jessica Faber, Ievgenii Liashenko, Jeanette Weigelt, Jörg Tessmar, Paul D. Dalton, Sibylle Jablonka, Mateo S. Andrade Mier, Carmen Villmann, Silvia Budday, Natascha Schaefer   +12 more
wiley   +1 more source

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]

, 2014
Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning, Aimee Parker, Andreu, Arber, Barker, Barker, Bashir, Berlanga-Acosta, Buczacki, Buske, Buske, Cairnie, Carmen Pin, Cheng, Cheng, Clarke, Clevers, Cummins, Cummins, Dehmer, Dekaney, Drasdo, Drasdo, Dunn, Durand, Edwards, Fauser, Galle, Hannezo, Haramis, Hirata, Humphries, Humphries, Hutter, Ian T. Johnson, Leushacke, Li, Li, Loeffler, Loeffler, Loeffler, Loeffler, Meineke, Milicic, Miyoshi, Nelson, Nelson, Ootani, Osborne, Pin, Pitt-Francis, Potten, Roth, Rothenberg, Sato, Sato, Sato, Sato, Simon R. Carding, Snippert, St Clair, Toshiro Sato, Totafurno, van Es, Wasan, Wong, Wright, Wright, Wright, Yuki Ohta   +69 more
core   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Generation of in vivo-like multicellular liver organoids by mimicking developmental processes: A review

Regenerative Therapy
Liver is involved in metabolic reactions, ammonia detoxification, and immunity. Multicellular liver tissue cultures are more desirable for drug screening, disease modeling, and researching transplantation therapy, than hepatocytes monocultures ...
Ayumu Okumura, Kenji Aoshima, Naoki Tanimizu   +2 more
doaj   +1 more source

Poking Pluripotency: Nanoinjection Into Human iPSCs

Advanced Materials, EarlyView.
Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts, Vuong Thi Thanh Xuan Ho, Yuqi Yang, Yuan Jiang, Roey Elnathan, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids [PDF]

, 2017
Treatment of common bile duct disorders such as biliary atresia or ischaemic strictures is limited to liver transplantation or hepatojejunostomy due to the lack of suitable tissue for surgical reconstruction.
Alexander, Graeme J., Bargehr, Johannes, Berntsen, Natalie Lie, Bertero, Alessandro, Brown, Stephanie, Casey, John, Davies, Susan E., de Brito, Miguel Cardoso, Gelson, William T.H., Georgakopoulos, Nikitas, Gieseck, Richard L., Godfrey, Edmund M., Gómez-Vázquez, María J., Hannan, Nicholas R.F., Jensen, Kim B., Justin, Alexander W., Karlsen, Tom H., Madrigal, Pedro, Markaki, Athina E., Materek, Paulina M., Melum, Espen, Ortmann, Daniel, Pawlowski, Matthias, Pedersen, Marianne T., Pirmadjid, Negar, Rimland, Casey A., Ross, Alexander, Saeb-Parsy, Kourosh, Sampaziotis, Fotios, Sawiak, Stephen, Shu, Wenmiao, Simonic, Ingrid, Sinha, Sanjay, Skeldon, Gregor M., Snijders, Kirsten, Tysoe, Olivia C., Upponi, Sara S., Valestrand, Laura, Vallier, Ludovic, Wynn, Thomas A., Yiangou, Loukia, Zilbauer, Matthias, Zonneveld, Mariëlle C.F.   +42 more
core   +7 more sources

Emerging frontiers in cHCC-CCA organoid models: bridging stem cell innovation to precision oncology

Egyptian Liver Journal
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare and complex liver malignancy characterized by diverse clinical features and unfavorable therapeutic responses.
Juntao Sun, Wenqing Liu, Ye Gao, Yuehuan Liu   +3 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source

Accelerated production of human epithelial organoids in a miniaturized spinning bioreactor

Cell Reports: Methods
Summary: Conventional static culture of organoids necessitates weekly manual passaging and results in nonhomogeneous exposure of organoids to nutrients, oxygen, and toxic metabolites.
Shicheng Ye, Ary Marsee, Gilles S. van Tienderen, Mohammad Rezaeimoghaddam, Hafsah Sheikh, Roos-Anne Samsom, Eelco J.P. de Koning, Sabine Fuchs, Monique M.A. Verstegen, Luc J.W. van der Laan, Frans van de Vosse, Jos Malda, Keita Ito, Bart Spee, Kerstin Schneeberger   +14 more
doaj   +1 more source