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Acta Biomaterialia, 2021 © 2021As life expectancy improves and the number of people suffering from various diseases increases, the need for developing effective personalized disease models is rapidly rising. The development of organoid technology has led to better recapitulation
Sewon Park, Seung-Woo Cho
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Updates on Organoid Model for the Study of Liver Cancer
Technology in Cancer Research and Treatment, 2023 Liver cancer remains one of the most common cancers worldwide with limited therapy options. The main risk factors for hepatocellular carcinoma (HCC), the most common form of liver cancer, include chronic infection with hepatitis B or hepatitis C viruses, alcohol abuse, and metabolic disease.
Caecilia H C Sukowati
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Hepatocyte Organoid Culture in Elliptic Hollow Fibers to Develop a Hybrid Artificial Liver
International Journal of Artificial Organs, 2004 A novel organoid culture was developed in which hepatocytes maintain high liver functions for more than several weeks in vitro. The main disadvantage of tissue-engineered organoids is the lack of a blood vessel structure between the aggregated cells ...
Junji Fukuda +2 more
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Culture of Mouse Liver Ductal Organoids
20223D organoid culture has become a powerful tool and model for various human diseases, including liver diseases, such as non-alcoholic steatohepatitis (NASH). Hepatic organoids have significant advantages over traditional primary cell cultures. The hepatic progenitor cells can be induced to form hepatic organoids.
Junkai, Yan, Yunling, Tai, Huiping, Zhou
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Advances in liver organoids: model systems for liver disease
Archives of Pharmacal Research, 2022Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Jaeseo Lee +4 more
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Engineering of an Hepatic Organoid to Develop Liver Assist Devices
Cell Transplantation, 2010 Cell-based technologies to support/restore liver function represent one of the most promising opportunities in the treatment of acute liver failure.
Nalu Navarro-Álvarez +2 more
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Organoids for Liver Stage Malaria Research
Trends in Parasitology, 2020Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
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Liver Organoids: Formation Strategies and Biomedical Applications
Tissue Engineering and Regenerative Medicine, 2021The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu +3 more
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Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro
Biomaterials, 2016 Current models for in vitro fibrosis consist of simple mono-layer cultures of rodent hepatic stellate cells (HSC), ignoring the role of hepatocyte injury.
Sofia B Leite +2 more
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2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
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The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
openaire +1 more source