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Liver Organoids: Formation Strategies and Biomedical Applications
Tissue Engineering and Regenerative Medicine, 2021The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models ...
Xinglong Zhu +3 more
openaire +2 more sources
2017
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
openaire +1 more source
The development of novel and consistent biologic surrogates for drug discovery, toxicology, and cancer research is presently intense and involves a growing number of research groups and institutions around the world. The Twilight of the days of immortalized cell lines as the workhorse of most of our drug development and cancer research efforts seem now
Solanas Villacampa, Estela Maria +6 more
openaire +1 more source
Ethical challenges for pediatric liver organoid transplantation
Science Translational Medicine, 2020The authors discuss whether it is ethically acceptable to include children in a first-in-human clinical trial of liver organoid transplantation.
Sarah A. Schneemann +5 more
openaire +2 more sources
Human liver organoids as in vitro models of the liver
Zeitschrift für Gastroenterologie, 2022K. Breitkopf-Heinlein +4 more
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PROLIFERATIVE LIVER ORGANOID, METABOLICCALY ACTIVATED LIVER ORGANOID, AND USE THEREOF
2021MASUDA NORIO, SATO TOSHIRO, IGARASHI RYO
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Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
Pharmacological Research, 2021Xiaowen Liang +2 more
exaly
Human Liver Organoid Models for Assessment of Drug Toxicity at the Preclinical Stage
Endocrine, Metabolic and Immune Disorders - Drug Targets, 2023Esra Erdal +2 more
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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Cell, 2022Takanori Takebe +2 more
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