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A cell atlas of multiple liver organoids and the fetal liver based on scRNA-seq. [PDF]
iScienceMa Q, Zhang X, Pan J.
europepmc +1 more source
Global trend of organoid implementation for hepatocellular carcinoma research (2005-2024): bibliometric analysis. [PDF]
Prz GastroenterolJi C, Zhao H, Shui Y, Zhao W, Qu L.
europepmc +1 more source
Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting. [PDF]
Cell Oncol (Dordr)Dai S +16 more
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Organoid transplant approaches for the liver
Transplant International, 2021 Organoid technology is a state-of-the-art cell culture tool that has revolutionized study of development, regeneration, and diseases. Human liver organoids (HLOs) are now derived from either adult stem/progenitors or pluripotent stem cells (PSCs), emulating cellular diversity and structural symphony akin to the human liver.
Takanori Takebe
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Animal and Organoid Models of Liver Fibrosis [PDF]
Frontiers in Physiology, 2021 Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver.
Xinli Mao, Shaowei Li
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Updates on Organoid Model for the Study of Liver Cancer
Technology in Cancer Research and Treatment, 2023 Liver cancer remains one of the most common cancers worldwide with limited therapy options. The main risk factors for hepatocellular carcinoma (HCC), the most common form of liver cancer, include chronic infection with hepatitis B or hepatitis C viruses, alcohol abuse, and metabolic disease.
Caecilia Sukowati, Korri El Khobar
exaly +4 more sources
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Culture of Mouse Liver Ductal Organoids
20223D organoid culture has become a powerful tool and model for various human diseases, including liver diseases, such as non-alcoholic steatohepatitis (NASH). Hepatic organoids have significant advantages over traditional primary cell cultures. The hepatic progenitor cells can be induced to form hepatic organoids.
Junkai, Yan, Yunling, Tai, Huiping, Zhou
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Advances in liver organoids: model systems for liver disease
Archives of Pharmacal Research, 2022Reliable in vitro models with human-derived cells that recapitulate in vivo-like physiologies are required for drug discovery and development to reduce the gap between the results of cell-based drug testing, animal testing, and human clinical trials. Liver organoid models have emerged as novel tools for hepatotoxicity evaluation, liver disease modeling,
Jaeseo Lee +4 more
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Organoids for Liver Stage Malaria Research
Trends in Parasitology, 2020Plasmodium parasites cause malaria and are maintained between Anopheles mosquitoes and mammalian hosts in a complex life cycle. Malaria parasites occupy tissue niches that can be difficult to access, and models to study them can be challenging to recapitulate experimentally, particularly for Plasmodium species that infect humans.
Ronan, Mellin, Justin A, Boddey
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