Results 211 to 220 of about 19,245 (266)

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function. [PDF]

Mater Today Bio
Ye S, Wang Z, Dirk Delemarre M, Liv N, van den Dikkenberg A, Vermonden T, van der Laan L, Malda J, Spee B, G Van Steenbeek F, Schneeberger-Verjaal K.   +10 more
europepmc   +1 more source

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Localized Accumulation of Tri‐n‐Propylamine Prolongs Electrochemiluminescence for Tumor Model Spheroid Analysis

Angewandte Chemie, EarlyView.
Here, we enhance the electrochemiluminescence imaging of cellular spheroids using [Ru(bpy)3]2+/TPrA chemistry. Our strategy, which involves pre‐incubation with TPrA, enables high‐resolution, long‐term visualization of cellular spheroids without phototoxicity.
Vanshika Gupta, Megan L. Hill, Samuel P. Nortz, Yashvi Choudhary, Ashutosh Rana, Jeffrey E. Dick   +5 more
wiley   +2 more sources

Organoids: From Bench to Bedside Applications. [PDF]

MedComm (2020)
Li K, Cao R, Li M, Tian Z, Fan H, Hong B, Liu X.   +6 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Automated and scalable expansion of human liver organoids for translational applications. [PDF]

J Transl Med
Ten Dam MJM, Jno Baptiste-Sam JS, Schwanen RS, van Uden L, Verstegen MMA, van der Laan LJW, Fuchs SA, Das R, Spee B.   +8 more
europepmc   +1 more source

Development of ovine hepatic organoids: a powerful <i>in vitro</i> platform to reduce the number of experimental animals used in metabolism and nutrition assays. [PDF]

Front Vet Sci
González-Montero MC, Criado M, Alonso M, Santos N, Gutiérrez-Expósito D, Giráldez FJ, Balaña-Fouce R, Andrés S, García-Estrada C.   +8 more
europepmc   +1 more source

Disease modelling with in vitro vascularised organoids. [PDF]

Dis Model Mech
Kan C, Liu L, Sugimura R.
europepmc   +1 more source

Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids. [PDF]

Cells
Yang J, Zhang X, Li S, Gao Z.
europepmc   +1 more source