Results 201 to 210 of about 18,518 (246)

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

High-throughput human microfluidic organoid-on-a-chip platform for modeling liver diseases and screening nanotherapeutics. [PDF]

J Nanobiotechnology
Kong D, Yu S, Heegsma J, Blokzijl T, Qin T, Pan Y, Blokzijl H, de Meijer VE, Duan Y, Faber KN, Xia Q, He K.   +11 more
europepmc   +1 more source

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

Disease-derived liver organoids as a preclinical screening platform identify Sargassum japonica as an anti-fibrotic candidate. [PDF]

Sci Rep
Heo J, Chae DH, Park HS, Yu A, Park JH, Cho K, Kim J, Lee H, Jee S, Kim C, Kong D, Seo Y, Kim HS, Bhang D, Park KS, Oh MK, Yu KR.   +16 more
europepmc   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, EarlyView.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Correlation between recognition of autologous tumor organoids by tumor-infiltrating lymphocytes from metastatic epithelial cancers and clinical response. [PDF]

J Immunother Cancer
Gustafson AM, Bhasin A, Gasmi B, Bui BD, Ade CM, Hanada KI, Halas HK, Gartner JJ, Prickett TD, Salazar J, Parkhust MR, Robbins P, Klemen ND, Kwong ML, Goff SL, Rosenberg SA, Yang JC.   +16 more
europepmc   +1 more source

Nanostructured Deep Eutectic Systems in Healthcare: From Bioactive Solvents to Intelligent Biointerfaces, Wearables, and AI‐Driven Design

Advanced NanoBiomed Research, EarlyView.
Beyond the green solvent paradigm, this review redefines Deep Eutectic Systems (DES) as programmable supramolecular nanoassemblies. We survey their biomedical convergence: stabilizing thermolabile mRNA to enable cold chain‐free logistics, reshaping transdermal microneedle delivery, enabling long‐term wearables via eutectogels, and utilizing Generative ...
Jeesu Moon, Min Seo Kim, Jae‐Seung Lee
wiley   +1 more source

Human organoids: Fit for drug discovery? [PDF]

Stem Cell Reports
Wittich A, Krieg K, Gribbon P, Metzger JJ, Prigione A, Pless O.   +5 more
europepmc   +1 more source

From Patient Liver Tissue to Organoids: Establishment of a Translational Platform Using Healthy, Steatotic, and Cirrhotic Tissue Sources. [PDF]

Cells
Pohlberger RF, Hardt KS, Kühnel MP, Palzer J, Reinhardt JL, Beetz O, Oldhafer F, Meister FA, Just KS, Schröder-Lange SK, Jonigk D, Vondran FWR, Weiskirchen R, Stiehl T, Roeth AA.   +14 more
europepmc   +1 more source

Human Organoids and Organ-on-Chip for Biotoxin Assessment: Applications, Best Practices, and a Translational Roadmap. [PDF]

Toxins (Basel)
Li M, Huang S, Jia J, Feng Y, Zhang J.
europepmc   +1 more source