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In recent years, use of hepatocyte aggregates has led to development of a hybrid artificial liver support system (HALSS) that has high performance. However, in general, their thickness is 100 μm or more, and generation of a dead cell layer due to oxygen
Kohji Nakazawa, T Kajiwara, K Funatsu
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Human liver organoids as in vitro models of the liver
Zeitschrift für Gastroenterologie, 2022K. Breitkopf-Heinlein +4 more
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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Cell, 2022Kentaro Iwasawa +2 more
exaly
Liver organoid as a 3D in vitro model for drug validation and toxicity assessment
Pharmacological Research, 2021Anastasia Brooks +2 more
exaly
[Progress and application of liver organoids in the study of liver cancer].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatologyThe incidence rate of liver cancer has been rising in recent years. Traditional cell line culture and human patient-derived tumor xenograft models, which are commonly used tools to simulate the occurrence of human liver cancer, have deepened the understanding of tumor occurrence, development, and drug resistance mechanisms. However, they cannot reflect
M, Wang +5 more
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Hybrid Artificial Liver Using Hepatocyte Organoid Culture
Artificial Organs, 2001K Funatsu +2 more
exaly

