Results 111 to 120 of about 35,405 (287)

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Construction of vascularized liver microtissues recapitulates angiocrine-mediated hepatocytes maturation and enhances therapeutic efficacy for acute liver failure

Bioactive Materials
Liver failure poses a significant challenge for millions of patients. The use of primary human hepatocytes and the engineering of liver organoids or liver tissue provide promising solutions to mitigate the shortage of donor organs.
Liuyang Zhu, Sen Liu, Zhuangzhuang Yang, Long Yang, Yueyue Yang, Pinsheng Han, Yu Miao, Lei Lin, Lilin Xu, Yan Li, Xinyue Li, Libo Wang, Tianyu Zhao, Weiwei Wang, Zilin Cui, Ze Wang, Deling Kong, Zhongyang Shen, Yamin Zhang   +18 more
doaj   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Liver-bone organoids reveal senescence-driven interorgan crosstalk

Bioactive Materials
The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication.
Yingting Zhang, Yue Li, Fuxiao Wang, Zhenglin Dong, Jian Wang, Yi Chen, Yinkun Fu, Yuheng Lu, Xinyu Bao, Yuxiao Lai, Yingying Jing, Jianhua Wang, Jianping Peng, Chao-Po Lin, Jiacan Su, Ming He   +15 more
doaj   +1 more source

Next-Generation Liver Medicine Using Organoid Models

Frontiers in Cell and Developmental Biology, 2019
“Liver medicine” refers to all diagnostic and treatment strategies of diseases and conditions that cause liver failure directly or indirectly. Despite significant advances in the field of liver medicine in recent years, improved tools are needed to ...
Soheil Akbari, Nur Arslan, Nur Arslan, Serif Senturk, Serif Senturk, Esra Erdal, Esra Erdal   +6 more
doaj   +1 more source

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies [PDF]

, 2021
Young‐Jun Choi, Melissa S. Kim, Joshua H. Rhoades, N. M. Johnson, Corbett T. Berry, Sarah Root, Qijun Chen, Yuhua Tian, Rafael Fernández, Zvi Cramer, Stephanie Adams‐Tzivelekidis, Ning Li, F. Brad Johnson, Christopher J. Lengner   +13 more
openalex   +1 more source

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source