Results 111 to 120 of about 23,262 (271)

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

Scientific Reports
Human liver organoids are in vitro three dimensionally (3D) cultured cells that have a bipotent stem cell phenotype. Translational research of human liver organoids for drug discovery has been limited by the challenge of their low hepatic function ...
Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi   +5 more
doaj   +1 more source

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

Cell Reports Medicine
Summary Steatotic liver disease (SLD) prevails as the most common chronic liver disease yet lack approved treatments due to incomplete understanding of pathogenesis.
K. Sasidharan, A. Caddeo, O. Jamialahmadi, F. Noto, M. Tomasi, F. Malvestiti, E. Ciociola, F. Tavaglione, R. Mancina, A. Cherubini, C. Bianco, A. Mirarchi, V. Männistö, J. Pihlajamäki, V. Kärjä, Stefania Grimaudo, P. Luukkonen, S. Qadri, Hannele Yki-Järvinen, Salvatore Petta, S. Manfrini, U. Vespasiani‐Gentilucci, Vincenzo Bruni, L. Valenti, Stefano Romeo   +24 more
semanticscholar   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Cholangiocyte Organoids in Liver Transplantation; a Comprehensive Review

Transplant International
Liver transplantation is the only curative option for many liver diseases that end up in liver failure, and cholangiopathy remains a challenging complication post-liver transplant, associated with significant morbidity and potential graft loss.
C. Rejas, H. Junger
doaj   +1 more source

A highly efficient cell culture method using oxygen‐permeable PDMS‐based honeycomb microwells produces functional liver organoids from human induced pluripotent stem cell‐derived carboxypeptidase M liver progenitor cells

Biotechnology and Bioengineering
Recent advancements in bioengineering have introduced potential alternatives to liver transplantation via the development of self‐assembled liver organoids, derived from human‐induced pluripotent stem cells (hiPSCs).
Tia Utami, Mathieu Danoy, R. Khadim, Fumiya Tokito, Hiroshi Arakawa, Yukio Kato, Taketomo Kido, Atsushi Miyajima, M. Nishikawa, Y. Sakai   +9 more
semanticscholar   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, EarlyView.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Construction of vascularized liver microtissues recapitulates angiocrine-mediated hepatocytes maturation and enhances therapeutic efficacy for acute liver failure

Bioactive Materials
Liver failure poses a significant challenge for millions of patients. The use of primary human hepatocytes and the engineering of liver organoids or liver tissue provide promising solutions to mitigate the shortage of donor organs.
Liuyang Zhu, Sen Liu, Zhuangzhuang Yang, Long Yang, Yueyue Yang, Pinsheng Han, Yu Miao, Lei Lin, Lilin Xu, Yan Li, Xinyue Li, Libo Wang, Tianyu Zhao, Weiwei Wang, Zilin Cui, Ze Wang, Deling Kong, Zhongyang Shen, Yamin Zhang   +18 more
doaj   +1 more source

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Liver-bone organoids reveal senescence-driven interorgan crosstalk

Bioactive Materials
The liver-bone axis plays a critical role in age-related diseases. However, current models inadequately capture its complex inter-organ communication.
Yingting Zhang, Yue Li, Fuxiao Wang, Zhenglin Dong, Jian Wang, Yi Chen, Yinkun Fu, Yuheng Lu, Xinyu Bao, Yuxiao Lai, Yingying Jing, Jianhua Wang, Jianping Peng, Chao-Po Lin, Jiacan Su, Ming He   +15 more
doaj   +1 more source