Results 131 to 140 of about 35,405 (287)

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research

Cells
Hepatocellular carcinomas (HCCs) are highly heterogeneous malignancies. They are characterized by a peculiar tumor microenvironment and dense vascularization.
Carlo Airola, Maria Pallozzi, Eleonora Cesari, Lucia Cerrito, Leonardo Stella, Claudio Sette, Felice Giuliante, Antonio Gasbarrini, Francesca Romana Ponziani   +8 more
doaj   +1 more source

Author Correction: Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density [PDF]

, 2023
Fuad Gandhi Torizal, Tia Utami, Qiao You Lau, Kousuke Inamura, Masaki Nishikawa, Yasuyuki Sakai   +5 more
openalex   +1 more source

A Soft Microrobot for Single‐Cell Transport, Spheroid Assembly, and Dual‐Mode Drug Screening

Advanced Materials, EarlyView.
A soft, untethered hydrogel microrobot enables precise single‐cell delivery, self‐assembly into 3D spheroids, and real‐time thermal actuation. Driven by light‐induced convection and embedded with gold nanorods and temperature sensors, the microrobot guides cells, modulates local microenvironments, and supports drug testing.
Philipp Harder, Nergishan İyisan, Yukun Wang, Berna Özkale   +3 more
wiley   +1 more source

Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage

Scientific Reports
Fibrolamellar carcinoma (FLC) is a type of primary liver cancer that predominantly affects healthy adolescents and young adults in a background of normal liver. The DNAJB1-PRKACA fusion gene is an oncogenic driver in FLC tumors.
Emma DiPietro, Nihal Bharath, Michael Karski, Olivia Durfee, Marc S. Sherman, Qianyi Ma, Liang Sun, Alaa R. Farghli, Colton J. Smith, Ina Kycia, Praveen Sethupathy, Wolfram Goessling, Michael S. Rogers, Khashayar Vakili   +13 more
doaj   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Tailored Xenogeneic‐Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells

Advanced Materials, EarlyView.
This study introduces a PoLymer‐coated Ultra‐stable Surface (PLUS), a nitrogen plasma‐treated poly(ethyleneglycoldimethacrylate), as a stable xenogeneic‐free platform for intestinal stem cell culture. PLUS enhances cell attachment, supports actin‐driven migration, and retains functionality after 3 years of storage. Promoting cytoskeletal reorganization,
Seonghyeon Park, Sang Yu Sun, Jin Gyeong Son, Sun Young Lee, Hyun Kyong Shon, Ohman Kwon, Minseok Lee, Keonwoo Choi, Jemin Yeun, Sung Hyun Yoon, Minkyung Kim, Mi‐Young Son, Tae Geol Lee, Sung Gap Im   +13 more
wiley   +1 more source

Dynamic, Reconfigurable, and Hierarchical Biosynthetic Composites via Collagen Self‐Assembly within Highly Crowded Microgel Pastes

Advanced Materials, EarlyView.
A new approach to extracellular matrix‐mimetic, hierarchical biomaterials is presented. Soft gels composed of overpacked hydrogel microparticle arrays present a biomolecularly crowded environment permissive to the self‐assembly of collagen networks.
Elif Narbay, Abbygail Caine, Sanika Pandit, Gabrielle Montgomery, Marion Harper, E. Daniel Cárdenas‐Vásquez, Hatte Hamilton, Megan Hicks, Daniel Mattar, Kyle Choy, Marco Bisoffi, L. Andrew Lyon   +11 more
wiley   +1 more source

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity [PDF]

, 2019
Ling Li, Hildur Knútsdóttir, Ken Hui, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Joel S. Bader, Florin M. Selaru   +13 more
openalex   +1 more source

Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids

, 2022
Jorke Willemse, Gilles van Tienderen, Eline V. A. van Hengel, Ivo J. Schurink, Diana L. van der Ven, Yik Y. Kan, Petra E. de Ruiter, Oskar Rosmark, Gunilla Westergren-Thorsson G, Kerstin Schneeberger, Bram C. J. van der Eerden, Henk P. Roest, Bart Spee, Luc J. W. van der Laan, Jeroen de Jonge, Monique M.A. Verstegen   +15 more
openalex   +1 more source