Results 31 to 40 of about 431,385 (241)

Liver X Receptors in Atherosclerosis and Inflammation [PDF]

Circulation Research, 2011
Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key regulators of lipid metabolism and transport but also suppress inflammatory signaling in macrophages through a unique mechanism of transrepression. In this brief review, we focus on the regulatory actions of LXR primarily in macrophages responding to a ...
Seung-Soon, Im, Timothy F, Osborne
openaire   +2 more sources

Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular ...
Rui Wang, Weibin Wu, Wen Li, Shuichuan Huang, Zilun Li, Ruiming Liu, Zhen Shan, Chunxiang Zhang, Wen Li, Shenming Wang   +9 more
doaj   +1 more source

Bile acids as global regulators of hepatic nutrient metabolism

Liver Research, 2017
Bile acids (BA) are synthesized from cholesterol in the liver. They are essential for promotion of the absorption of lipids, cholesterol, and lipid-soluble vitamins from the intestines.
Phillip B. Hylemon, Kazuaki Takabe, Mikhail Dozmorov, Masayuki Nagahashi, Huiping Zhou   +4 more
doaj   +1 more source

Expression of liver X receptor-α in lesional and perilesional skin in patients with psoriasis vulgaris

Journal of the Egyptian Women’s Dermatologic Society, 2021
Background Psoriasis is a common chronic recurrent immune-mediated disease of the skin. Liver X receptor-alpha (LXR-α) is a member of the nuclear receptor family of transcription factors. LXR-α was found to be expressed in the skin.
Azza G.A Farag, Alaa H Maree, Rehab M Samaka, Mai A.A Zalata, Wafaa A Shehata   +4 more
doaj   +1 more source

Liver X Receptor Signaling Pathways and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR receptors encoded by distinct genes: LXRα is most highly expressed in the liver, adipose, kidney, adrenal tissues, and macrophages and LXRβ is ubiquitously expressed ...
Anna C, Calkin, Peter, Tontonoz
openaire   +2 more sources

Bile Acid Nuclear Receptor Farnesoid X Receptor: Therapeutic Target for Nonalcoholic Fatty Liver Disease [PDF]

Endocrinology and Metabolism, 2016
Nonalcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver, occurring when fat is accumulated in the liver without alcohol consumption. NAFLD is the most common liver disorder in advanced countries.
Sun-Gi Kim, Byung-Kwon Kim, Kyumin Kim, Sungsoon Fang   +3 more
doaj   +1 more source

Loss of liver X receptor β in astrocytes leads to defects in early postnatal hippocampal neurogenesis in mice

Di-san junyi daxue xuebao, 2022
Objective To investigate the effects of specific liver X receptor β (LXRβ) knockout in astrocytes on early postnatal hippocampal neurogenesis in mice. Methods Cre/loxP system was used to construct a mouse model with specific LXRβ knockout in astrocyte ...
LYU Keyi, LUO Yi, LI Xin, XIAO Rui, CHEN Sheng, XIE Ruxin, FAN Xiaotang, CHEN Hong   +7 more
doaj   +1 more source

Liver X Receptor: A novel therapeutic target

Indian Journal of Pharmaceutical Sciences, 2008
The liver X receptors alpha and beta are orphan nuclear receptors that are key regulators in maintaining cholesterol homeostasis. Originally they were found to play an important role in reverse cholesterol transport, a pathway for the removal of excess cellular cholesterol. However several groups have now shown that the liver X receptors also functions
Patel, M. B., Oza, N. A., Anand, I. S., Deshpande, S. S., Patel, C. N.   +4 more
openaire   +3 more sources

Liver X receptors and fat cell metabolism [PDF]

International Journal of Obesity, 2012
Liver X receptors (LXRs) are members of the nuclear receptor family and are present in two isoforms, α and β, encoded by two separate genes. Originally described in the liver, LXRs have in the last 15 years been implicated in central metabolic pathways, including bile acid synthesis, lipid and glucose homeostasis.
Laurencikiene, J, Rydén, M
openaire   +2 more sources

Exploring Preferences for a Digital Single‐Session Intervention for Adolescent Siblings of Youth With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Adolescent siblings of children with cancer are at elevated risk for psychosocial problems. Unfortunately, various barriers such as limited family time and resources, conflicting schedules, and psychosocial staffing constraints at cancer centers hinder sibling access to support.
Christina M. Amaro, Sarah Silver, Prishi Patel, Meredith K. Reffner Collins, Kimberly S. Canter, Stephanie Fooks‐Parker, Michael Amylon, Shawna V. Hudson, Jessica L. Schleider, Melissa A. Alderfer, Katie A. Devine   +10 more
wiley   +1 more source