Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8 [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundThe role of vitamin D in Coronavirus Disease 2019 (COVID-19) outcomes remains debated, but emerging evidence suggests it may enhance recovery by strengthening immune responses.
Annika Roth +23 more
doaj +2 more sources
Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model [PDF]
Cell Adhesion & Migration, 2023 The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells.
Huidan Zhang +5 more
doaj +2 more sources
Antimicrobial peptide LL-37 increases rhinovirus-induced interferon β expression in human airway epithelial cells through a Ca2+-dependent mechanism [PDF]
Biochemistry and Biophysics ReportsThe human cathelicidin LL-37 is active against both bacteria and viruses, but it also shows immunomodulatory properties. Here, we assess the impact of LL-37 on viral signaling in human airway epithelial BEAS-2B cells infected with the respiratory ...
Samuel Cerps +6 more
doaj +2 more sources
LL-37 Triggers Antimicrobial Activity in Human Platelets. [PDF]
Int J Mol Sci, 2023 Platelets play a crucial role in hemostasis and the immune response, mainly by recognizing signals associated with vascular damage. However, it has recently been discovered that the antimicrobial peptide LL-37 activates platelets in functions related to thrombus formation and inflammation.
Sánchez-Peña FJ +7 more
europepmc +3 more sources
Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation
Frontiers in Immunology, 2023 Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk.
Qing Zhang +6 more
doaj +1 more source
The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent
Antibiotics, 2021 The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from antibiotic ...
Kylen E. Ridyard, Joerg Overhage
doaj +1 more source
Frontiers in Immunology, 2022 Human cathelicidin (LL-37) is a defense peptide with antimicrobial activity against various pathogens. However, LL-37 can also trigger tissue injury by binding to host cell membranes.
Lidia de Tapia +4 more
doaj +1 more source
Defense of the Skin with LL-37 [PDF]
Journal of Investigative Dermatology, 2009 As the first line of defense against invading organisms, the skin uses a multiplicity of processes to ensure host survival, including physical, immunological, and innate systems of defense. The innate immune system, which defends skin in a nonspecific fashion, includes the cathelicidins and the single currently known human cathelicidin, hCAP18.
Bouzari, Navid +2 more
openaire +2 more sources
LL-37 induces polymerization and bundling of actin and affects actin structure. [PDF]
PLoS ONE, 2012 Actin exists as a monomer (G-actin) which can be polymerized to filaments) F-actin) that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton.
Asaf Sol +3 more
doaj +1 more source
The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity
Scientific Reports, 2022 Beneficial effects of vitamin D on COVID-19 progression have been discussed in several studies. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, and evidence shows that LL-37 can antagonize SARS-CoV-2.
Matthias Keutmann +7 more
doaj +1 more source