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Defense of the Skin with LL-37 [PDF]
Journal of Investigative Dermatology, 2009 As the first line of defense against invading organisms, the skin uses a multiplicity of processes to ensure host survival, including physical, immunological, and innate systems of defense. The innate immune system, which defends skin in a nonspecific fashion, includes the cathelicidins and the single currently known human cathelicidin, hCAP18.
Bouzari, Navid +2 more
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Frontiers in Immunology, 2022 Human cathelicidin (LL-37) is a defense peptide with antimicrobial activity against various pathogens. However, LL-37 can also trigger tissue injury by binding to host cell membranes.
Lidia de Tapia +4 more
doaj +1 more source
Regulation of LL-37 in Bone and Periodontium Regeneration
Life, 2022 The goal of regenerative therapy is to restore the structure and function of the lost tissues in the fields of medicine and dentistry. However, there are some challenges in regeneration therapy such as the delivery of oxygen and nutrition, and the risk of infection in conditions such as periodontitis, osteomyelitis, etc. Leucine leucine-37 (LL-37) is a
Zahra Chinipardaz +2 more
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The Role of Cathelicidin LL-37 in Cancer Development [PDF]
Archivum Immunologiae et Therapiae Experimentalis, 2015 LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions.
Ewelina Piktel +8 more
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Human defensins and LL-37 in mucosal immunity [PDF]
Journal of Leukocyte Biology, 2009 Abstract Defensins and LL-37 play key roles in maintaining mucosal barriers against invasive infection and initiating immune responses after infection or injury to mucosal surfaces. Defensins are widespread in nature and have activity against a broad range of pathogens.
Mona, Doss +3 more
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LL-37 induces polymerization and bundling of actin and affects actin structure. [PDF]
PLoS ONE, 2012 Actin exists as a monomer (G-actin) which can be polymerized to filaments) F-actin) that under the influence of actin-binding proteins and polycations bundle and contribute to the formation of the cytoskeleton.
Asaf Sol +3 more
doaj +1 more source
Impact of LL-37 on anti-infective immunity [PDF]
Journal of Leukocyte Biology, 2004 AbstractHost defense peptides (often called cationic antimicrobial peptides) have pleiotropic immunomodulatory functions. The human host defense peptide LL-37 is up-regulated at sites of infection and has little or no antimicrobial activity in tissue-culture media but under the same conditions, demonstrates immunomodulatory effects on epithelial cells,
Dawn M E, Bowdish +5 more
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Cathelicidin LL-37 in Health and Diseases of the Oral Cavity
Biomedicines, 2022 The mechanisms for maintaining oral cavity homeostasis are subject to the constant influence of many environmental factors, including various chemicals and microorganisms. Most of them act directly on the oral mucosa, which is the mechanical and immune barrier of the oral cavity, and such interaction might lead to the development of various oral ...
Joanna Tokajuk +8 more
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The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity
Scientific Reports, 2022 Beneficial effects of vitamin D on COVID-19 progression have been discussed in several studies. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, and evidence shows that LL-37 can antagonize SARS-CoV-2.
Matthias Keutmann +7 more
doaj +1 more source
Bone Reports, 2020 Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm ...
Zhifang Zhang +5 more
doaj +1 more source