Results 31 to 40 of about 56,247,789 (275)
The Antimicrobial Peptide, LL-37, Inhibits in vitro Osteoclastogenesis [PDF]
Journal of Dental Research, 2012 Uncoupled bone resorption leads to net alveolar bone loss in periodontitis. The deficiency of LL-37, the only human antimicrobial peptide in the cathelicidin family, in patients with aggressive periodontitis suggests that LL-37 may play a pivotal role in the inhibition of alveolar bone destruction in periodontitis.
Supanchart, C. +6 more
openaire +5 more sources
Biochemistry and Biophysics Reports, 2022 The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported.
Elisabeth Bankell +6 more
doaj +1 more source
Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. [PDF]
PLoS ONE, 2015 The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection.
Shweta Tripathi +5 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
doaj +1 more source
Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. [PDF]
PLoS ONE, 2011 BackgroundHuman cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In this study, we investigated the role of LPS neutralisation in mediating LL-37's ability
Aaron Scott +9 more
doaj +1 more source
Involvement of the Antimicrobial Peptide LL-37 in Human Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Objective— Antimicrobial peptides are effector molecules of the innate immune system. To understand the function of vascular innate immunity in atherosclerosis, we investigated the role of LL-37, a cathelicidin antimicrobial peptide, in the disease process.
Kristina, Edfeldt +7 more
openaire +2 more sources
Characterizing the role of cell-wall β-1,3-exoglucanase Xog1p in Candida albicans adhesion by the human antimicrobial peptide LL-37. [PDF]
PLoS ONE, 2011 Candida albicans is the major fungal pathogen of humans. Its adhesion to host-cell surfaces is the first critical step during mucosal infection. Antimicrobial peptides play important roles in the first line of mucosal immunity against C.
Pei-Wen Tsai +3 more
doaj +1 more source
Cell Death Discovery, 2022 Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an essential component of the human immune system. Accumulating evidence has indicated that hCAP18/LL-37 plays a tissue-specific role in human cancer.
Huidan Zhang +7 more
doaj +1 more source
The Roles of Cathelicidin LL-37 in Inflammatory Bowel Disease [PDF]
Inflammatory Bowel Diseases, 2016 Human cathelicidin LL-37, the only member of the cathelicidin family of host defense peptides expressed in humans, plays a crucial role in host defense against pathogen invasion, as well as in regulating the functions of anti-inflammation, antitumorigenesis, and tissue repair.
Lihua, Sun +3 more
openaire +2 more sources
LL-37 Triggers Antimicrobial Activity in Human Platelets
International Journal of Molecular Sciences, 2023 Platelets play a crucial role in hemostasis and the immune response, mainly by recognizing signals associated with vascular damage. However, it has recently been discovered that the antimicrobial peptide LL-37 activates platelets in functions related to thrombus formation and inflammation.
Francisco Javier Sánchez-Peña +7 more
openaire +2 more sources