Biochemistry and Biophysics Reports, 2022 The human antimicrobial peptide LL-37 permeabilizes the plasma membrane of host cells, but LL-37-induced direct effects on mitochondrial membrane permeability and function has not been reported.
Elisabeth Bankell +6 more
doaj +1 more source
Antimicrobial peptides and eicosanoids : roles and interactions in inflammation and host defense [PDF]
, 2017 Antimicrobial peptides (AMPs) have a broad spectrum of activities and exert their functions by both direct killing of microbes through the interaction with the microbial membrane, and modulation of innate and adaptive immunity of the host.
Tang, Xiao
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Regulation of LL-37 in Bone and Periodontium Regeneration
Life, 2022 The goal of regenerative therapy is to restore the structure and function of the lost tissues in the fields of medicine and dentistry. However, there are some challenges in regeneration therapy such as the delivery of oxygen and nutrition, and the risk of infection in conditions such as periodontitis, osteomyelitis, etc. Leucine leucine-37 (LL-37) is a
Zahra Chinipardaz +2 more
openaire +3 more sources
Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. [PDF]
PLoS ONE, 2015 The human cathelicidin LL-37 has been shown to play a role in host defense against influenza A viruses (IAV) through direct antiviral effects and through modulating inflammatory responses to infection.
Shweta Tripathi +5 more
doaj +1 more source
Role of antimicrobial peptides in tuberculosis and respiratory tract infections : clinical and mechanistic studies [PDF]
, 2015 Antimicrobial peptides (AMPs) are effector molecules of the innate immune system in multicellular organisms. They are mainly expressed in epithelial cells and immune cells, providing the first line of defense against a wide range of pathogens.
Rekha, Rokeya Sultana
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Frontiers in Bioscience-Landmark, 2021 Human cathelicidin antimicrobial peptide LL-37 (LL-37) is an antimicrobial peptide derived from its precursor protein hCAP18, which is an only cathelicidin in human.
Keqiang Chen +4 more
doaj +1 more source
Bicarbonate induces high-level resistance to the human antimicrobial peptide LL-37 in Staphylococcus aureus small colony variants [PDF]
, 2017 Objectives: Staphylococcus aureus small colony variants (SCVs) cause persistent infections and are resistant to cationic antibiotics. Antimicrobial peptides (AMPs) have been suggested as promising alternatives for treating antibiotic-resistant bacteria ...
Nair, SP, Tymon, A, Wright, JA, Zhang, P
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Significance of LL‐37 on Immunomodulation and Disease Outcome
BioMed Research International, 2020 LL‐37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function.
Binbin Yang +11 more
openaire +4 more sources
Evaluation of the ability of LL-37 to neutralise LPS in vitro and ex vivo. [PDF]
PLoS ONE, 2011 BackgroundHuman cathelicidin LL-37 is a cationic antimicrobial peptide (AMP) which possesses a variety of activities including the ability to neutralise endotoxin. In this study, we investigated the role of LPS neutralisation in mediating LL-37's ability
Aaron Scott +9 more
doaj +1 more source
Antimicrobial peptides, disease severity and exacerbations in bronchiectasis [PDF]
, 2019 Rationale: Recently a frequent exacerbator phenotype has been described in bronchiectasis, but the underlying biological mechanisms are unknown. Antimicrobial peptides (AMPs) are important in host defence against microbes but can be proinflammatory in ...
Aliberti, Stefano +14 more
core +2 more sources