Results 41 to 50 of about 1,333,743 (274)
The Roles of Cathelicidin LL-37 in Inflammatory Bowel Disease [PDF]
Inflammatory Bowel Diseases, 2016 Human cathelicidin LL-37, the only member of the cathelicidin family of host defense peptides expressed in humans, plays a crucial role in host defense against pathogen invasion, as well as in regulating the functions of anti-inflammation, antitumorigenesis, and tissue repair.
Lihua, Sun +3 more
openaire +2 more sources
Cell Death Discovery, 2022 Cathelicidin hCAP18/LL-37 can resist infection from various pathogens and is an essential component of the human immune system. Accumulating evidence has indicated that hCAP18/LL-37 plays a tissue-specific role in human cancer.
Huidan Zhang +7 more
doaj +1 more source
LL-37 Triggers Antimicrobial Activity in Human Platelets
International Journal of Molecular Sciences, 2023 Platelets play a crucial role in hemostasis and the immune response, mainly by recognizing signals associated with vascular damage. However, it has recently been discovered that the antimicrobial peptide LL-37 activates platelets in functions related to thrombus formation and inflammation.
Francisco Javier Sánchez-Peña +7 more
openaire +2 more sources
LL-37 signaling increases CovS phosphatase activity.
, 2018 (A) Representative Western blot (top) and bar representation (bottom) depicting CovR~P levels and (B) hasA transcript levels (means ± standard deviations, n = 4) of indicated GAS strains grown to mid-exponential phase in THY or THY supplemented with ...
Nicola Horstmann (201711) +8 more
core +1 more source
Frontiers in Immunology, 2018 The human host defense peptide LL-37 promotes immune activation such as induction of chemokine production and recruitment of leukocytes. Conversely, LL-37 also mediates anti-inflammatory responses such as production of anti-inflammatory cytokines, e.g ...
Mahadevappa Hemshekhar +4 more
doaj +1 more source
Sequence and the expression construct of SP-LL-37.
, 2017 (A) Nucleotide sequence of SP-LL-37 containing the coding region and stop codon as well as the signal peptide (underlined). (B) Schematic diagram of the expression construct pSP1::SP-LL-37. Detection of Nos gene copy numbers in the T0 generation of pPZP::
Md. Amdadul Huq (3829780) +6 more
core +1 more source
PharmaceuticsBackground/Objectives: Glioblastomas (GBMs) are the most malignant and intractable of all cancers, with an unfavorable clinical prognosis for affected patients. The objective was to analyze the sensitivity of GBM cells to the antimicrobial peptides (AMPs)
Alexander N. Chernov +9 more
doaj +1 more source
Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses. [PDF]
PLoS ONE, 2015 Human LL-37, a cationic antimicrobial peptide, was recently shown to have antiviral activity against influenza A virus (IAV) strains in vitro and in vivo.
Shweta Tripathi +5 more
doaj +1 more source
Identification of pPZP::SP-LL-37 insertion transgenic plants.
, 2017 The genomic structures of insertion alleles were determined by FST analysis in which boxes, bold lines, and triangles indicate exons, intron, and pPZP::SP-LL-37, respectively.
Md. Amdadul Huq (3829780) +6 more
core +1 more source
Pharmaceuticals, 2016 Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been emerging, and antimicrobial peptides (AMPs) have been considered to be ...
I-Ni Hsieh, Kevan L. Hartshorn
doaj +1 more source