Results 61 to 70 of about 1,333,743 (274)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Modulation of exogenous antibiotic activity by host cathelicidin LL‐37 [PDF]

APMIS, 2010
Leszczyńska K, Namiot A, Janmey PA, Bucki R. Modulation of exogenous antibiotic activity by host cathelicidin LL‐37. APMIS 2010; 118: 830–6.The increasing number of infections caused by drug‐resistant bacteria has spurred efforts to develop new therapeutic strategies. When applied locally, exogenous antibiotics work in an environment rich in endogenous
Katarzyna Leszczyńska, Andrzej Namiot, Janmey, Paul, Robert Bucki   +3 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Copy number frequency of pPZP::SP-LL-37 in transgenic plants.

, 2017
Copy number frequency of pPZP::SP-LL-37 in transgenic plants.
Md. Amdadul Huq (3829780), Ill Sup Nou (3829783), In Hye Lee (3829786), Yong Gu Cho (33571), Kwon-Kyoo Kang (121864), Franz Marielle Nogoy (3829789), Yu-Jin Jung (467121)   +6 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Agronomic traits of pPZP:: SP-LL-37 T₁ homo lines.

, 2017
Agronomic traits of pPZP:: SP-LL-37 T1 homo lines.
Md. Amdadul Huq (3829780), Ill Sup Nou (3829783), In Hye Lee (3829786), Yong Gu Cho (33571), Kwon-Kyoo Kang (121864), Franz Marielle Nogoy (3829789), Yu-Jin Jung (467121)   +6 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

LL-37-induced activation of caspase-1 in P. aeruginosa infected epithelial cells, and induction of neutrophil migration, is mediated by lysosomal leakage of cathepsin B.

, 2019
A) Confocal microscopy images of NHBE cells loaded with Alexa 488 Dextran (green) +/- treatment with TAMRA-labelled LL-37 (red), with white arrows indicating lysosomal leakage, quantified in (B ...
Hsin-Ni Li (6585674), Lisa Young (5634554), Adriano G. Rossi (330009), Brian J. McHugh (317010), Julia R. Dorin (476192), Rebekah Kells (6585677), Paula E. Beaumont (571026), Robert D. Gray (677167), Donald J. Davidson (341314), Emily L. Gwyer Findlay (6585680), Rongling Wang (6585671), Holly Stevens (3211086), David Brough (324992)   +12 more
core   +1 more source

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

, 2020
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and ...
Shakamuri, Priyanka, Casanova, Víctor, Buch, Chloé, Christophorou, Maria A., Pohl, Jan, Barlow, Peter G., Stevens, Craig, D'Acremont, Mathilde, Sousa, Filipa Henderson, Svoboda, Pavel   +9 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source