Results 61 to 70 of about 191,557 (278)

Evaluation of Cathelicidin (LL-37) Serum Levels Among Iraqi Psoriatic Patients and Its Association with Disease Severity and Complications

مجلة الكوفة الطبية
Background: Psoriasis is a chronic skin condition distinguished by inflammation and the rapid proliferation of skin cells, leading to scaly, red patches.
Rasool Moussa Bader Al-asade, Suaad Mohammed Hassan   +1 more
doaj   +1 more source

Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro [PDF]

, 2018
Background: There is a need to prevent and treat infection in newborns. One approach is administration of antimicrobial proteins and peptides (APPs) such as LL-37, a membrane-active cathelicidin antimicrobial peptide, and mannose-binding lectin (MBL), a ...
Borriello, Francesco, Jeffers, Carleen, Joshi, Sweta, Levy, Ofer, Li, Ning, Ozonoff, Al, Pettengill, Matthew, Scheid, Annette   +7 more
core   +1 more source

Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions [PDF]

, 2009
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldVernix caseosa is a white cream-like substance that covers the skin of the foetus and the newborn baby.
Agerberth, B, Bergsson, G, Griffiths, W, Gudmundsson, G H, Haraldsson, A, Jörnvall, H, Kai-Larsen, Y, Lengqvist, J, Sjövall, J, Skuladottir, G V, Tollin, M   +10 more
core   +1 more source

Vitamin D triggers hCAP18/LL-37 production: Implications for LL-37-induced human osteoblast cytotoxicity

Biochemical and Biophysical Research Communications
The human cathelicidin LL-37 shows activity against microorganisms, but it is also cytotoxic to host cells. The CAMP gene codes for the LL-37 precursor hCAP18 which is processed extracellularly to active LL-37. It has previously been shown that vitamin D stimulates CAMP gene activity, but less information is available demonstrating that vitamin D also ...
Alexandra Aidoukovitch, Elisabeth Bankell, Daniel Svensson, Bengt-Olof Nilsson   +3 more
openaire   +2 more sources

Investigation of LL-37-mediated siRNA transfection

TURKISH JOURNAL OF BIOLOGY, 2013
RNA interference is not only an important tool for studying protein function; it also holds many promises for the treatment of a variety of diseases in which the function of unwanted proteins needs to be suppressed. For small interfering RNA (siRNA) to be used as a therapeutic agent, the biggest hurdle is to find the right delivery agent that is both ...
Mustafa YALÇINKAYA, Şahru YÜKSEL
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The di-leucine motif in the host defense peptide LL-37 is essential for initiation of autophagy in human macrophages

Cell Reports
Summary: The human cathelicidin peptide LL-37 induces autophagy in human macrophages. Different post-translational modifications (PTMs) such as citrullination, acetylation, and formylation impact LL-37, yet their effect on autophagy remains unknown. Thus,
Rokeya Sultana Rekha, Avinash Padhi, Nicolai Frengen, Julia Hauenstein, Ákos Végvári, Birgitta Agerberth, Robert Månsson, Guðmundur H. Guðmundsson, Peter Bergman   +8 more
doaj   +1 more source

Direct effects of fermented cow's milk product with Lactobacillus paracasei CBA L74 on human enterocytes [PDF]

, 2018
Cow's milk fermented with Lactobacillus paracasei CBA L74 (FM-CBAL74) exerts a preventive effect against infectious diseases in children. We evaluated if this effect is at least in part related to a direct modulation of non-immune and immune defence ...
C. Bruno, C. Fierro, L. Paparo, R. Aitoro, R. Berni Canani, R. Nocerino   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source