Results 71 to 80 of about 1,333,743 (274)

LL-37 induced HA metabolism in SW982 cell line.

, 2019
SW982 cells were treated with 12.5 ng/mL of LL-37 for varied times. Cells were then collected and measured for the expression of HAS2, HAS3, HYAL1, HYAL2 and CD44 genes, respectively (A-E). The values from triplicate experiments are expressed as the mean
Nutnicha Sirikaew (6900452), Supitcha Thonghoi (6900458), Siriwadee Chomdej (6616448), Rungnaree Jaitham (6900455), Chakkrapong Kuensaen (6900449), Patiwat Kongdang (6616445), Siriwan Ongchai (6616439)   +6 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Chitosan hydrogel encapsulated with LL-37 peptide promotes deep tissue injury healing in a mouse model

Military Medical Research, 2020
Background LL-37 peptide is a member of the human cathelicidin family, and has been shown to promote the healing of pressure ulcers. However, the low stability of this peptide within the wound environment limits its clinical use.
Xu Yang, Jing-Lin Guo, Jing Han, Rui-Juan Si, Pan-Pan Liu, Zi-Rui Zhang, Ai-Min Wang, Ju Zhang   +7 more
doaj   +1 more source

Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model

Cell Adhesion & Migration, 2023
The effect of cathelicidin hCAP18/LL-37 in hepatocellular carcinoma (HCC) metastasis remains unclear. Here, we confirmed that LL-37 expression enhanced endothelial-mesenchymal transition (EMT), migration and invasion in HCC cells.
Huidan Zhang, Xueli Yuan, Yaxin Yang, Yangke Wanyan, Liping Tao, Yuqing Chen   +5 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

LL-37-mediated activation of caspase-1 during airway epithelial cell infection with P. aeruginosa is NLRP3-dependent.

, 2019
Airway epithelial cells, either WT NHBE cells (A), NLRP3 siRNA treated 16HBE14o- cells (B), or NLRP3 CRISPR stable 16HBE14o- cell lines (C), were exposed for 3 hours to media only (control), 20 μg/ml LL-37, PAO1 at 10:1 MOI, PAO1 + LL-37.
Hsin-Ni Li (6585674), Lisa Young (5634554), Adriano G. Rossi (330009), Brian J. McHugh (317010), Julia R. Dorin (476192), Rebekah Kells (6585677), Paula E. Beaumont (571026), Robert D. Gray (677167), Donald J. Davidson (341314), Emily L. Gwyer Findlay (6585680), Rongling Wang (6585671), Holly Stevens (3211086), David Brough (324992)   +12 more
core   +1 more source

Elevated levels of the antimicrobial peptide LL-37 in hidradenitis suppurativa are associated with a Th1/Th17 immune response. [PDF]

, 2018
Hidradenitis suppurativa (HS) is an inflammatory skin disease with poorly understood immunopathogenic mechanisms. LL-37 is an antimicrobial peptide, which is transcribed from the CAMP (cathelicidin antimicrobial peptide) gene.
Nikhil Yawalkar, Rahel Thomi, Daniel Yerly, Schlapbach, Christoph, Dagmar Simon, Yerly, Daniel, Hunger, Robert, Christoph Schlapbach, Robert E. Hunger, Thomi, Rahel, Yawalkar, Nikhil, Simon, Dagmar   +11 more
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

The Human Antimicrobial Peptide LL-37 Suppresses Apoptosis in Keratinocytes [PDF]

Journal of Investigative Dermatology, 2009
The human cathelicidin antimicrobial peptide LL-37 is involved in various aspects of skin biology, including protection against infection, wound healing, and also in psoriasis. The tight regulation of apoptosis is critical in tissue repair and its deregulation is a part of the psoriasis phenotype.
Chamorro, Cl., Weber, Gunther, Gronberg, A., Pivarcsi, A., Stahle, Mona   +4 more
openaire   +3 more sources

PREPARATION AND STABILITY EVALUATION OF LL-37 CREAM

International Journal of Applied Pharmaceutics, 2021
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a ...
ELIZA MIRANDA, KUSMARINAH BRAMONO, LUDDWI ACHMAD RIZKY, null HAYUN   +3 more
openaire   +2 more sources