Results 81 to 90 of about 191,557 (278)

Cathelicidins—Therapeutic antimicrobial and antitumor host defense peptides for oral diseases

Japanese Dental Science Review, 2011
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. Several types of host defense peptides (HDPs), including defensins, cathelicidins, and histatins, may have important roles in innate host defense.
Kazuhiko Okumura
doaj   +1 more source

Functional dualism of antimicrobial host defence peptides [PDF]

, 2009
Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes.
Björstad, Åse
core  

Flagellin induces β-defensin 2 in human colonic ex vivo infection with enterohemorrhagic Escherichia coli [PDF]

, 2016
Enterohemorrhagic E. coli (EHEC) is an important foodborne pathogen in the developed world and can cause life-threatening disease particularly in children.
Chan, Simon, Cook, Vivienne, Ellis, Samuel, Gelson, William, Lewis, Steven, Prior, Alison, Schuller, Stephanie   +6 more
core   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. [PDF]

, 2014
Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S.
Cunningham, Mark L, Fenical, William, Haste, Nina M, Hensler, Mary E, Jang, Kyoung Hwa, Kwan, Bryan P, Lin, Leo, Nizet, Victor, Shaw, Karen Joy, Soubih, Evaristus, Thienphrapa, Wdee, Tran, Dan N, Vuong, Lisa   +12 more
core   +1 more source

PREPARATION AND STABILITY EVALUATION OF LL-37 CREAM

International Journal of Applied Pharmaceutics, 2021
Objective: The present study aimed to prepare LL-37 in a cream formulation (O/W emulsion) and evaluate its stability by determining the physical changes in the cream and concentration of LL-37 using validated high-performance liquid chromatography. Methods: The method was conducted at room temperature using a C18 column (5 µm × 250 mm × 4.6 mm) as a ...
ELIZA MIRANDA, KUSMARINAH BRAMONO, LUDDWI ACHMAD RIZKY, null HAYUN   +3 more
openaire   +2 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Cathelicidin suppresses lipid accumulation and hepatic steatosis by inhibition of the CD36 receptor. [PDF]

, 2016
Background and objectivesObesity is a global epidemic which increases the risk of the metabolic syndrome. Cathelicidin (LL-37 and mCRAMP) is an antimicrobial peptide with an unknown role in obesity.
Bakirtzi, K, Cheng, M, Fisseha, E, Fleshner, P, Gallo, RL, Hing, TC, Ho, S, Hoang-Ngoc Tran, D, Hoang-Yen Tran, D, Karagiannides, I, Koon, HW, Law, I, Lee, EC, Lee, JE, Li, Z, Mattai, SA, McGovern, DPB, Ortiz, C, Robbins, L, Sallam, T, Shieh, C, Shih, DQ, Sideri, A, Su, B, Targan, SR, Vu, M   +25 more
core   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source