Results 11 to 20 of about 56,247,789 (275)

Significance of LL‐37 on Immunomodulation and Disease Outcome [PDF]

BioMed Research International, 2020
LL‐37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function.
Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi, Ming Q. Wei   +11 more
openaire   +5 more sources

SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice. [PDF]

PLoS ONE, 2017
Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus.
In Hye Lee, Yu-Jin Jung, Yong Gu Cho, Ill Sup Nou, Md Amdadul Huq, Franz Marielle Nogoy, Kwon-Kyoo Kang   +6 more
doaj   +2 more sources

Serum LL‐37 and inflammatory cytokines levels in psoriasis

Immunity, Inflammation and Disease, 2023
Background Psoriasis (PsO) is a T‐cell‐associated inflammatory autoimmune dermatitis. Leucine leucine‐37 (LL‐37) is upregulated in PsO patients and correlated with the area and severity of PsO.
Juanfeng Lao, Zhi Xie, Qunshi Qin, Ru Qin, Shangyang Li, Yulin Yuan   +5 more
doaj   +3 more sources

Vitamin D triggers hCAP18/LL-37 production: Implications for LL-37-induced human osteoblast cytotoxicity

Biochemical and Biophysical Research Communications
The human cathelicidin LL-37 shows activity against microorganisms, but it is also cytotoxic to host cells. The CAMP gene codes for the LL-37 precursor hCAP18 which is processed extracellularly to active LL-37. It has previously been shown that vitamin D stimulates CAMP gene activity, but less information is available demonstrating that vitamin D also ...
Alexandra Aidoukovitch, Elisabeth Bankell, Daniel Svensson, Bengt-Olof Nilsson   +3 more
openaire   +3 more sources

Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer [PDF]

Cellular Physiology and Biochemistry, 2018
LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis. Accumulating evidence indicates that LL-37 also plays a significant role in human cancer.
Xi Chen, Xianqiong Zou, Guangying Qi, Ying Tang, Yong Guo, Jia Si, Lihua Liang   +6 more
openaire   +4 more sources

Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses

bchm, 2009
Abstract Cathelicidins are effector molecules of the innate host defense system that establish an antimicrobial barrier at epithelial interfaces. The human cathelicidin LL-37, in addition to its antimicrobial activity, also exhibits immunomodulatory effects, such as inhibition of pro-inflammatory responses to bacterial LPS in human ...
Molhoek, E.M., den Hertog, A.L., de Vries, A.M.B.C., Nazmi, K., Veerman, E.C.I., Hartgers, F.C., Yazdanbakhsh, M., Bikker, F.J., van der Kleij, D.   +8 more
core   +8 more sources

LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis [PDF]

Inflammation plays a crucial role in the host immune system, and it involves a complex network of cellular and molecular events. In the lungs, human bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to facilitate and regulate airway inflammation.
Ramotar, Padmanie
openaire   +2 more sources

The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent

Antibiotics, 2021
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from antibiotic ...
Kylen E. Ridyard, Joerg Overhage
doaj   +1 more source

Defense of the Skin with LL-37 [PDF]

Journal of Investigative Dermatology, 2009
As the first line of defense against invading organisms, the skin uses a multiplicity of processes to ensure host survival, including physical, immunological, and innate systems of defense. The innate immune system, which defends skin in a nonspecific fashion, includes the cathelicidins and the single currently known human cathelicidin, hCAP18.
Bouzari, Navid, Kim, Nancy, Kirsner, Robert S.   +2 more
openaire   +2 more sources

The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro

Frontiers in Immunology, 2022
Human cathelicidin (LL-37) is a defense peptide with antimicrobial activity against various pathogens. However, LL-37 can also trigger tissue injury by binding to host cell membranes.
Lidia de Tapia, Belén García-Fojeda, Nina Kronqvist, Jan Johansson, Cristina Casals   +4 more
doaj   +1 more source