Results 11 to 20 of about 1,333,743 (274)

Significance of LL‐37 on Immunomodulation and Disease Outcome

BioMed Research International, 2020
LL‐37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function.
Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi, Ming Q. Wei   +11 more
openaire   +5 more sources

SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice. [PDF]

PLoS ONE, 2017
Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus.
In Hye Lee, Yu-Jin Jung, Yong Gu Cho, Ill Sup Nou, Md Amdadul Huq, Franz Marielle Nogoy, Kwon-Kyoo Kang   +6 more
doaj   +2 more sources

Carbamylated LL-37 as a modulator of the immune response [PDF]

Innate Immunity, 2016
Carbamylation of lysine residues and protein N-termini is an ubiquitous, non-enzymatic post-translational modification. Carbamylation at sites of inflammation is due to cyanate formation during the neutrophil oxidative burst and may target lysine residues within the antimicrobial peptide LL-37. The bactericidal and immunomodulatory
Koro, Catalin, Hellvard, Annelie, Delaleu, Nicolas, Binder, Veronika, Scavenius, Carsten, Bergum, Brith, Główczyk, Izabela, Roberts, Helen M, Chapple, Iain Lc, Grant, Melissa M, Rapala-Kozik, Maria, Klaga, Kinga, Enghild, Jan J; id_orcid 0000-0001-9292-9172, Potempa, Jan, Mydel, Piotr   +14 more
openaire   +6 more sources

Vitamin D triggers hCAP18/LL-37 production: Implications for LL-37-induced human osteoblast cytotoxicity

Biochemical and Biophysical Research Communications
The human cathelicidin LL-37 shows activity against microorganisms, but it is also cytotoxic to host cells. The CAMP gene codes for the LL-37 precursor hCAP18 which is processed extracellularly to active LL-37. It has previously been shown that vitamin D stimulates CAMP gene activity, but less information is available demonstrating that vitamin D also ...
Alexandra Aidoukovitch, Elisabeth Bankell, Daniel Svensson, Bengt-Olof Nilsson   +3 more
openaire   +3 more sources

Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8 [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundThe role of vitamin D in Coronavirus Disease 2019 (COVID-19) outcomes remains debated, but emerging evidence suggests it may enhance recovery by strengthening immune responses.
Annika Roth, Steffen Lütke, Steffen Lütke, Matthias Mörgelin, Matthias Mörgelin, Denise Meinberger, Gabriele Hermes, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Manuel Koch, Manuel Koch, Manuel Koch, Marco Drexelius, Jan Gebauer, Ines Neundorf, Dzemal Elezagic, Mats Paulsson, Mats Paulsson, Mats Paulsson, Thomas Streichert, Andreas R. Klatt   +23 more
doaj   +2 more sources

Antimicrobial peptide LL-37 increases rhinovirus-induced interferon β expression in human airway epithelial cells through a Ca2+-dependent mechanism [PDF]

Biochemistry and Biophysics Reports
The human cathelicidin LL-37 is active against both bacteria and viruses, but it also shows immunomodulatory properties. Here, we assess the impact of LL-37 on viral signaling in human airway epithelial BEAS-2B cells infected with the respiratory ...
Samuel Cerps, Sangeetha Ramu, Olof Gidlöf, Mandy Menzel, Karl Swärd, Lena Uller, Bengt-Olof Nilsson   +6 more
doaj   +2 more sources

Immunomodulatory effects of LL-37 in the epithelia

, 2008
The cationic host defence peptide LL-37 is an immunomodulatory agent that plays an important role in epithelial innate immunity. Previously, concentrations of LL-37 thought to represent levels present during inflammation have been shown to elicit the production of cytokines and chemokines by epithelial cells.
Filewod, Niall Christopher Jack
openaire   +2 more sources

Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation

Frontiers in Immunology, 2023
Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk.
Qing Zhang, Qing Zhang, Qurrat Ul Ain, Christian Schulz, Christian Schulz, Joachim Pircher, Joachim Pircher   +6 more
doaj   +1 more source

LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis

Inflammation plays a crucial role in the host immune system, and it involves a complex network of cellular and molecular events. In the lungs, human bronchial epithelial cells release cytokines/chemokines, and other mediators such as bioactive lipids and cationic host defence peptides (CHDPs) to facilitate and regulate airway inflammation.
Ramotar, Padmanie
openaire   +2 more sources

The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-Biofilm Agent

Antibiotics, 2021
The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat bacterial infections. The development of novel therapeutic agents is crucial in avoiding a post-antibiotic era and the associated deaths from antibiotic ...
Kylen E. Ridyard, Joerg Overhage
doaj   +1 more source