Results 21 to 30 of about 188,935 (276)
Endogenous antimicrobial peptide LL-37 induces human vasodilatation [PDF]
British Journal of Anaesthesia, 2008 Septic shock includes blood vessel dilatation and activation of innate immunity, which in turn causes release of antimicrobial peptides such as LL-37. It has been shown that LL-37 can attract leucocytes via the lipoxin A(4) receptor (ALX, FPRL1). ALX is also present in vascular endothelial cells. To explore possible ways of pharmacological intervention
I, Berkestedt, A, Nelson, M, Bodelsson
openaire +2 more sources
Frontiers in Pharmacology, 2022 Pancreatic cancer is amongst the most lethal malignancies, while its poor prognosis could be associated with promotion of autophagy and the tumor immune microenvironment.
Zhu Zhang +14 more
doaj +1 more source
Impact of LL-37 on anti-infective immunity [PDF]
Journal of Leukocyte Biology, 2004 AbstractHost defense peptides (often called cationic antimicrobial peptides) have pleiotropic immunomodulatory functions. The human host defense peptide LL-37 is up-regulated at sites of infection and has little or no antimicrobial activity in tissue-culture media but under the same conditions, demonstrates immunomodulatory effects on epithelial cells,
Dawn M E, Bowdish +5 more
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Bone Reports, 2020 Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm ...
Zhifang Zhang +5 more
doaj +1 more source
Human defensins and LL-37 in mucosal immunity [PDF]
Journal of Leukocyte Biology, 2009 Abstract Defensins and LL-37 play key roles in maintaining mucosal barriers against invasive infection and initiating immune responses after infection or injury to mucosal surfaces. Defensins are widespread in nature and have activity against a broad range of pathogens.
Mona, Doss +3 more
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Cathelicidin LL-37 Ignites Primed NLRP3 Inflammasomes in Rosacea [PDF]
Journal of Investigative Dermatology, 2021 Microbes and commensal mites contribute to the development of inflammation and neurovascular dysregulation in rosacea. Cathelicidin family proteins are epithelial antimicrobial peptides expressed in higher-order mammals. In humans, mature LL-37 is cleaved from its precursor in response to microbial infection, UV light, and injury.
David O. Croitoru, Vincent Piguet
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SP-LL-37, human antimicrobial peptide, enhances disease resistance in transgenic rice. [PDF]
PLoS ONE, 2017 Human LL-37 is a multifunctional antimicrobial peptide of cathelicidin family. It has been shown in recent studies that it can serve as a host's defense against influenza A virus.
In Hye Lee +6 more
doaj +1 more source
Effects of LL-37 on Gingival Fibroblasts: A Role in Periodontal Tissue Remodeling? [PDF]
, 2018 Mounting evidence suggests that the host defence peptide, LL-37, plays a role in both inflammation and in wound healing; however, the role of this peptide in the remodeling and maintenance of oral tissues is not yet fully understood.
Irwin, Chris R. +3 more
core +1 more source
The Role of Cathelicidin LL-37 in Cancer Development [PDF]
Archivum Immunologiae et Therapiae Experimentalis, 2015 LL-37 is a C-terminal peptide proteolytically released from 18 kDa human cathelicidin protein (hCAP18). Chronic infections, inflammation, tissue injury and tissue regeneration are all linked with neoplastic growth, and involve LL-37 antibacterial and immunomodulatory functions.
Piktel, Ewelina +8 more
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Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]
, 2015 BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L +6 more
core +10 more sources