Results 71 to 80 of about 188,935 (276)

Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI

Pediatric Blood &Cancer, EarlyView.
Abstract Introduction The TEDDI trial tested the feasibility and reproducibility of deep‐inspiration breath‐hold (DIBH) in pediatric patients referred for radiotherapy. This report presents final results, including patient‐reported outcomes (PRO) and dosimetric comparison of DIBH and free‐breathing (FB).
Daniella Elisabet Østergaard, Anni Young Lundgaard, Laura Ann Rechner, Danijela Dejanovic, Hanne Krogh Rose, Jolanta Hansen, Leila Vaalavirta, Miia Mokka, Marianne Aznar, Peder Skov Wehner, Lisa Lyngsie Hjalgrim, Maja Vestmø Maraldo   +11 more
wiley   +1 more source

Intestinal antimicrobial gene expression: impact of micronutrients in malnourished adults during a randomized trial. [PDF]

, 2010
BACKGROUND: Because both micronutrients and antimicrobial peptides protect against diarrhea, we looked for an effect on intestinal antimicrobial peptide gene expression during a randomized controlled trial of multiple micronutrient (MM) supplementation ...
Bevins, Charles L, Dhaliwal, Winnie, Jagatiya, Poonam, Kelly, Paul, Khanam, Moriam, Ndulo, Namwiinga, Sanderson, Ian R, Shawa, Tamara, Simuyandi, Michelo   +8 more
core   +1 more source

Modulation of exogenous antibiotic activity by host cathelicidin LL‐37 [PDF]

APMIS, 2010
Leszczyńska K, Namiot A, Janmey PA, Bucki R. Modulation of exogenous antibiotic activity by host cathelicidin LL‐37. APMIS 2010; 118: 830–6.The increasing number of infections caused by drug‐resistant bacteria has spurred efforts to develop new therapeutic strategies. When applied locally, exogenous antibiotics work in an environment rich in endogenous
Katarzyna, Leszczyńska, Andrzej, Namiot, Paul A, Janmey, Robert, Bucki   +3 more
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

The Host Defense Peptide LL-37 Selectively Permeabilizes Apoptotic Leukocytes [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACTLL-37 is a cationic host defense peptide that is highly expressed during acute inflammation and that kills bacteria by poorly defined mechanisms, resulting in permeabilization of microbial membranes. High concentrations of LL-37 have also been reported to have cytotoxic effects against eukaryotic cells, but the peptide is clearly capable of ...
Björstad, Ase, Askarieh, Galia, Brown, Kelly L, Christenson, Karin, Forsman, Huamei, Onnheim, Karin, Li, Hsin-Ni, Teneberg, Susann, Maier, Olaf, Hoekstra, Dick, Dahlgren, Claes, Davidson, Donald J, Bylund, Johan   +12 more
openaire   +4 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Functional dualism of antimicrobial host defence peptides [PDF]

, 2009
Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes.
Björstad, Åse
core  

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus. [PDF]

, 2014
Anthracimycin is a recently discovered novel marine-derived compound with activity against Bacillus anthracis. We tested anthracimycin against an expanded panel of Staphylococcus aureus strains in vitro and in vivo. All strains of S.
Cunningham, Mark L, Fenical, William, Haste, Nina M, Hensler, Mary E, Jang, Kyoung Hwa, Kwan, Bryan P, Lin, Leo, Nizet, Victor, Shaw, Karen Joy, Soubih, Evaristus, Thienphrapa, Wdee, Tran, Dan N, Vuong, Lisa   +12 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Cathelicidins—Therapeutic antimicrobial and antitumor host defense peptides for oral diseases

Japanese Dental Science Review, 2011
The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. Several types of host defense peptides (HDPs), including defensins, cathelicidins, and histatins, may have important roles in innate host defense.
Kazuhiko Okumura
doaj   +1 more source