Results 31 to 40 of about 103,530 (319)
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 542-549, December 2022., 2022 Schematic diagram showing RHAU can bind and unwind the G4 “knots” to modulate embryonic development and post‐natal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis and organ dysfunction. RHAU modulates Nkx2‐5 mRNA and Yap1 mRNA at the post‐transcriptional level and facilitates the transcription of c‐Kit and ...
Chensi Yang +5 more
wiley +1 more source
Inferring cell-specific lncRNA regulation with single-cell RNA-sequencing data in the developing human neocortex [PDF]
arXiv, 2022 Long non-coding RNAs (lncRNAs) are important regulators to modulate gene expression and cell proliferation in the developing human brain. Previous methods mainly use bulk lncRNA and mRNA expression data to study lncRNA regulation. However, to analyze lncRNA regulation regarding individual cells, we focus on single-cell RNA-sequencing (scRNA-seq) data ...
arxiv
Pyroptosis-related lncRNAs Predict Prognosis of Laryngeal Cancer
Zhongliu Fangzhi Yanjiu, 2022 Objective To construct a prognostic model of laryngeal cancer based on pyroptosis-related lncRNAs. Methods Transcriptome expression and clinical data of patients with laryngeal cancer were downloaded from TCGA database.
LIU Changjian, WANG Jian, LIU Shaoyan
doaj +1 more source
Establishment of LncRNA Risk Prediction Model for Glioblastoma Based on TCGA Database
Zhongliu Fangzhi Yanjiu, 2019 Objective To establish a risk score model of LncRNA for the prognosis of glioblastoma patients using TCGA database. Methods The gene expression profiles and clinical data of glioblastoma and normal nerve tissues in TCGA database were downloaded to screen
PENG Hui +4 more
doaj +1 more source
Research Progress of LncRNA and Other Epigenetics in Triple-negative Breast Cancer
Zhongliu Fangzhi Yanjiu, 2020 For lacking of HR and HER-2, triple-negative breast cancer (TNBC) is one type of breast cancers with the worst prognosis. The current treatments are mainly chemotherapy, radiotherapy and surgery, but the results are still not satisfactory, which leads us
SUN Hanxiao, ZHANG Fenghua
doaj +1 more source
LncRNA expression in idiopathic achalasia: New insight and preliminary exploration into pathogenesis
Open Medicine, 2022 Idiopathic achalasia is a primary esophageal motility disorder characterized by the absence of esophageal peristalsis and impaired relaxation of the lower esophageal sphincter (LES). However, the pathogenesis of idiopathic achalasia remains unclear.
Lu Chao +4 more
doaj +1 more source
Oncotarget, 2016 Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation.
Xiaoyi Huang +5 more
openalex +4 more sources
Cancer Management and Research, 2021 Xiaoning Cen,1,* Yunmei Huang,2,* Zhuangnian Lu,3,* Wenjun Shao,4 Chenyi Zhuo,1 Chongchan Bao,5 Shi Feng,5 Cheng Wei,5 Xiqiang Tang,5 Lijun Cen,5 Wenwen Guo,5 Xinru Tian,5 Qianli Tang,5 Xusen Huang1 1General Surgery, Affiliated Hospital of ...
Cen X +13 more
doaj
Non-Coding RNA, 2020 Immunological diseases, including asthma, autoimmunity and immunodeficiencies, affect a growing percentage of the population with significant unmet medical needs.
Riccardo Guidi +2 more
doaj +1 more source
A four-lncRNA signature for predicting prognosis of recurrence patients with gastric cancer
Open Medicine, 2021 This study aimed to develop a multi-long noncoding RNA (lncRNA) signature for the prediction of gastric cancer (GC) based on differential gene expression between recurrence and nonrecurrence patients.
Chen Qiang +6 more
doaj +1 more source