Results 71 to 80 of about 167,789 (348)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Role of LncRNAs in Translation [PDF]

, 2021
Didem Karakaş, Bülent Özpolat
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Self-assembled fluorescent hybrid nanoparticles-mediated collaborative lncRNA CCAT1 silencing and curcumin delivery for synchronous colorectal cancer theranostics [PDF]

, 2021
Jia Fan, Yunhao Li, Xiongwei Deng, Xuan Wang, Xinyue Cui, Jianqing Lu, Zian Pan, Yan Wu   +7 more
openalex   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

lncRNA-ACOD1: GOT2 has got a lncRNA cofactor

Non-coding RNA Investigation, 2018
In spite of the limited information encoded in viral genomes, viruses can infect and replicate in complex organisms. Evolution has selected viruses able to use cellular factors to achieve viral entry, viral protein expression, and viral replication, packaging and release.
Marina Barriocanal, Puri Fortes
openaire   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Exosomal lncRNA SHNG7 Promotes High-Grade Serous Ovarian Cancer Progression and Function As ceRNA to Target Notch1 By Sponging miR-34a-5p [PDF]

, 2021
Jing Cui, Lu Xue, Weiting Gu, Cunzhong Yuan, Hui Zhang   +4 more
openalex   +1 more source

LncRNA RPPH1 promotes colorectal cancer metastasis by interacting with TUBB3 and by promoting exosomes-mediated macrophage M2 polarization

Cell Death and Disease, 2019
Metastasis is a well-known poor prognostic factor in cancer. However, the mechanisms how long non-coding RNAs (lncRNAs) regulate metastasis in colorectal cancer (CRC) remain largely unknown.
Zhenxing Liang, Huashan Liu, Feng-wei Wang, Li Xiong, Chi Zhou, Tuo Hu, Xiao-wen He, Xiao-Jian Wu, D. Xie, Xian-rui Wu, P. Lan   +10 more
semanticscholar   +1 more source

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Nature Communications, 2020
Interacting with proteins is a crucial way for long noncoding RNAs (lncRNAs) to exert their biological responses. Here we report a high throughput strategy to characterize lncRNA interacting proteins in vivo by combining tobramycin affinity purification ...
Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, M. Xiao, Baicai Yang, Guoxuan Qin, R. Kong, Ruibing Chen, Ning Zhang   +10 more
semanticscholar   +1 more source