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LncRNA XIST Promotes Atherosclerosis by Regulating miR-599/TLR4 Axis
Inflammation, 2021Long noncoding RNAs (lncRNAs) have been reported to be implicated in various biological and pathological processes. However, the function and mechanism of XIST in vascular smooth muscle cells (VSMCs) remains unknown. The levels of XIST, miR-599, and TLR4 were tested by RT-qPCR.
Kechun Yang, Yun Xue, Xiaoya Gao
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Conformation and structural dynamics of the Xist lncRNA A-repeats
2022ABSTRACT LncRNAs are emerging to play crucial roles in the regulation of many essential cellular processes and have been linked to human disease, but a detailed understanding of their structure and how this relates to underlying molecular mechanisms is still limited.
Alisha N. Jones +4 more
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LncRNA NKILA Inhibits Retinoblastoma by Downregulating lncRNA XIST
Current Eye Research, 2019Purpose: Although retinoblastoma is rare but can be deadly in some severe cases. To find novel therapeutic targets for retinoblastoma, we explored the potential role of lncRNA NKILA in retinoblastoma. Results: We found that, comparing to healthy controls, NKILA was downregulated, while lncRNA XIST was upregulated in plasma of retinoblastoma patients ...
Xueman, Lyu +4 more
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The Ambivalent Role of lncRNA Xist in Carcinogenesis
Stem Cell Reviews and Reports, 2019Long non-coding RNA (lncRNA) Xist has emerged as a key modulator in dosage compensation by randomly inactivating one of the X chromosomes in mammals during embryonic development. Dysregulation of X chromosome inactivation (XCI) due to deletion of Xist has been proven to induce hematologic cancer in mice.
Yung-Kang, Chen, Yun, Yen
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Current Problems in Cancer, 2021
Long noncoding RNAs (lncRNAs) are evolving as contributing biomarkers for many diseases. Among these lncRNAs, X inactive-specific transcript (XIST), and nuclear paraspeckle assembly transcript 1 (NEAT1) were studied as undesirable upregulated nucleic acid markers for unfavorable prognosis of cancer.
Menha Swellam +5 more
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Long noncoding RNAs (lncRNAs) are evolving as contributing biomarkers for many diseases. Among these lncRNAs, X inactive-specific transcript (XIST), and nuclear paraspeckle assembly transcript 1 (NEAT1) were studied as undesirable upregulated nucleic acid markers for unfavorable prognosis of cancer.
Menha Swellam +5 more
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LncRNA XIST modulates HIF‐1A/AXL signaling pathway by inhibiting miR‐93‐5p in colorectal cancer
Molecular Genetics & Genomic Medicine, 2020 Background Long noncoding RNA (LncRNA) XIST is one of the genes that exists in different types of cancers. Earlier researches showed that XIST can advance the progression of colorectal cancer.
Qin-Li Sun
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LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS
Journal of Bone and Mineral Metabolism, 2022The diagnosis and treatment of osteoporosis, a frequent age-related metabolic bone disorder, remain incomprehensive and challenging. The potential regulatory role of lncRNA XIST and sphingosine kinase 1 (SPHK1) pathway need experimental investigations.RAW264.7 cells and BMMs were obtained for in vitro studies and 30 ng/mL RANKL was implemented for ...
Da-Wei Zhang +5 more
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Mechanism of LncRNA XIST/ miR-101–3p/ZEB1 axis in EMT associated with silicosis
Toxicology Letters, 2022Silicosis is a systemic disease characterized by diffuse fibrosis of lung tissue. However, its pathogenesis has not been fully elucidated. Previous studies have demonstrated that there is a close relationship between EMT and pulmonary fibrosis. However, LncRNA XIST and miR-101-3p regulate the expression of ZEB1 which is a key transcription factor in ...
Changfu Hao, Wu Yao, Yuanmeng Qi
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LncRNA-XIST Promotes Lung Adenocarcinoma Growth and Inhibits Ferroptosis by Regulating GPX4
Molecular Biotechnology, 2023This study aimed to explore the regulatory effects and molecular mechanisms of long non-coding RNA X-inactive-specific transcript (LncRNA-XIST) in lung adenocarcinoma. si-XIST or glutathione peroxidase 4 (GPX4) plasmids were transfected in PC-9 cells to suppress LncRNA-XIST expression or over-express GPX4, respectively.
Chen-lin Lu, Jie Liu, Jun-fa Yang
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Autoimmunity, 2021 The role and mechanism of lncRNA XIST (XIST) in the development of rheumatoid arthritis (RA) was explored in this study. RT-qPCRs were performed to detect the expression of XIST and miR-126-3p in synovial tissues and cells.
Wei Zhong +4 more
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