Results 61 to 70 of about 33,716 (178)
Cancer Science, EarlyView.Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang +6 more
wiley +1 more source
ImmunobiologyAlzheimer's disease (AD) is often accompanied by retinal lesions, in which Amyloid β (Aβ) is a key mediator. Vascular dysfunction is always associated with the malignant progression of AD, but the precise mechanisms remain poorly understood.
Bin Wang +7 more
doaj +1 more source
Cell Death and Disease, 2021 Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play critical roles in human diseases. We aimed to clarify the role of lncRNA X-inactive specific transcript (XIST)/miR-149-3p/forkhead box P3 (FOXP3) axis in ovarian cancer (OC) cell growth.
Rong Jiang +13 more
doaj +1 more source
Epigenetic Regulation in the Pathogenesis of Periodontitis
Journal of Periodontal Research, EarlyView.The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch +3 more
wiley +1 more source
Probing Xist RNA Structure in Cells Using Targeted Structure-Seq. [PDF]
PLoS Genetics, 2015 The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how Xist and other lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the
Rui Fang +3 more
doaj +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Stomach cancer (SC) or gastric cancer (GC) is one of the most common gastrointestinal malignancies. Currently, some studies based on competing endogenous RNAs (ceRNA) network analysis have been assessed for this cancer. The construction and analysis of ceRNA network is a novel approach for identification of RNA‐based biomarkers in cancer ...
Habib MotieGhader +2 more
wiley +1 more source
Beyond sequence homology: Cellular biology limits the potential of XIST to act as a miRNA sponge.
PLoS ONE, 2019 IntroductionThe sponging of microRNAs by a long non-coding RNA (lncRNA) away from their coding gene targets is a conceptually-simple, yet biologically-complex method of lncRNA-mediated gene regulation.
Erin A Marshall +4 more
doaj +1 more source
ELE: Estimating tissue‐specific long noncoding RNA gene essentiality using graph neural networks
Quantitative Biology, Volume 14, Issue 4, December 2026.Abstract A gene is essential if its loss of function results in lethality, reduced fitness, or disease. Essential genes have attracted increasing attention due to their vital functions in biological systems. Many efforts have been made to find essential protein‐coding genes.
Wan‐Ting Shi +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 49, 3 September 2026.Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv +13 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2021 The prevalence of ossification of the posterior longitudinal ligament (OPLL) is increasing, and currently there is no effective medical treatment for OPLL.
Xiaoqiu Yuan +6 more
doaj +1 more source