Results 41 to 50 of about 33,716 (178)

DataSheet_1_Effect of LncRNA XIST on Immune Cells of Primary Biliary Cholangitis.pdf

, 2022
ObjectivePrimary biliary cholangitis (PBC) is an autoimmune disease with significant gender difference. X chromosome inactivation (XCI) plays important roles in susceptibility to diseases between genders.
Bin Liu (5899), Qixuan Liu (2445208), Chunhui She (12194288), Patrick S. C. Leung (11271105), Yuan Yao (31223), Yifei Yang (585215), Bo Zang (12194291)   +6 more
core   +1 more source

Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats

Journal of Molecular Cell Biology, 2019
Abstract Following the discovery of numerous long non-coding RNA (lncRNA) transcripts in the human genome, their important roles in biology and human disease are emerging. Recent progress in experimental methods has enabled the identification of structural features of lncRNAs.
Alisha N Jones, Michael Sattler
openaire   +3 more sources

Silencing of HuR Inhibits Osteosarcoma Cell Epithelial-Mesenchymal Transition via AGO2 in Association With Long Non-Coding RNA XIST

Frontiers in Oncology, 2021
BackgroundOsteosarcoma (OS) is a highly malignant and aggressive bone tumor. This study was performed to explore the mechanisms of HuR (human antigen R) in the progression of OS.MethodsHuR expression levels in OS tissues and cells were detected by ...
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +12 more
doaj   +1 more source

Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome [PDF]

, 2015
This work was supported by the Biotechnology and Biological Sciences Research Council and The Wellcome Trust. A.N. was supported by the Swiss National Science Foundation (Grant: PZ00P3_142636). H.K. was supported by the European Research Council Starting
Ness, Rob W, Keightley, Peter D, Kaessmann, H., Keightley, P. D., Halligan, D. L., Ness, R. W., Wiberg, R.A., Wiberg, Ralf Axel Wilhelm, Halligan, Daniel L, Ness, R.W., Keightley, P.D., Keightley, Peter D., Kaessmann, Henrik, Wiberg, R. A., Wiberg, R Axel W, Ness, Rob W., Necsulea, A., Halligan, D.L., Halligan, Daniel L., Necsulea, Anamaria   +19 more
core   +1 more source

LncRNA XIST promotes inflammation by downregulating GRα expression in the adenoids of children with OSAHS

Experimental and Therapeutic Medicine, 2021
Whether glucocorticoid receptor α (GRα) serves a role in obstructive sleep apnea/hypopnea syndrome (OSAHS) remains unclear. However, it has been reported that GRα expression is decreased in the adenoids of patients with OSAHS. The present study aimed to evaluate the role of GRα in OSAHS and the underlying mechanism.
Zhou, Zhen, Ni, Haifeng, Li, Yong, Jiang, Bo   +3 more
openaire   +3 more sources

Long Non-coding RNA X-Inactive Specific Transcript Mediates Cell Proliferation and Intrusion by Modulating the miR-497/Bcl-w Axis in Extranodal Natural Killer/T-cell Lymphoma

Frontiers in Cell and Developmental Biology, 2020
The present study was directed toward laying new findings for Extranodal natural killer/T-cell lymphoma (ENKL)-oriented therapy with a focus on long non-coding RNA (lncRNA)–microRNAs (miRNAs)–mRNA interaction.
Qinhua Liu, Ruonan Ran, Zhengsheng Wu, Xiaodan Li, Qingshu Zeng, Ruixiang Xia, Yalei Wang   +6 more
doaj   +1 more source

SViswanathanLab/XIST-Males-Scripts: v1.0.0

, 2022
Somatic XIST activation and features of X chromosome inactivation in male human cancers [Sadagopan et al.
as1000, Mingkee Achom, inasim1998
core   +1 more source

lncRNA XIST promotes glioma proliferation and metastasis through miR‑133a/SOX4

Experimental and Therapeutic Medicine, 2020
Glioma is the most common malignant brain tumour in adults, and the aetiology and mechanism of this tumour remain largely unknown. Previous studies have demonstrated that the long non-coding RNA X-inactive specific transcript (XIST) is upregulated in many cancers, and a high expression level of XIST is associated with poor clinical outcome.
Luo, Chixing, Quan, Zhongping, Zhong, Bao, Zhang, Ming, Zhou, Bo, Wang, Shaobo, Luo, Xinkai, Tang, Changjiu   +7 more
openaire   +3 more sources

Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Arthritis Research & Therapy, 2019
Background Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases.
Hongwei Chen, Shengdi Yang, Ruyi Shao
doaj   +1 more source

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and ...
Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin   +3 more
doaj