Results 31 to 40 of about 33,716 (178)
Pan-cancer analysis of LncRNA XIST and its potential mechanisms in human cancers. [PDF]
Heliyon, 2022 X-inactive specific transcript (XIST), it has been found, is abnormal expression in various neoplasms. This work aims to explore its potential molecular mechanisms and prognostic roles in types of malignancies.This research comprehensively investigated XIST transcription across cancers from Oncomine, TIMER 2.0 and GEPIA2.
Han W +8 more
europepmc +4 more sources
A novel lncRNA-miRNA-mRNA triple network identifies lncRNA XIST as a biomarker for acute myocardial infarction. [PDF]
Aging (Albany NY), 2022 Despite the well-established role of long non-coding RNAs (lncRNAs) across various biological processes, their mechanisms in acute myocardial infarction (AMI) are not fully elucidated. The GSE34198 dataset from the Gene Expression Omnibus (GEO) database, which comprised 49 specimens from individuals with AMI and 47 specimens from controls, was ...
Zheng PF +4 more
europepmc +3 more sources
LncRNA XIST regulates atherosclerosis progression in ox-LDL-induced HUVECs [PDF]
Open Medicine, 2021 Abstract Long noncoding RNAs (lncRNAs) have been verified as vital regulators in human disease, including atherosclerosis. However, the precise role of X-inactive-specific transcript (XIST) in atherosclerosis remains unclear. The proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs) exposed to low-density ...
Gao Hongmei, Guo Zhaohui
openaire +3 more sources
Journal of International Medical Research, 2021 Objective To evaluate the predictive value of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) for survival, and determine the involvement of miRNA(miR)-200b-3p and zinc finger E-box-binding homeobox (ZEB) 1/2 in the pro-tumor effect of
Lili Liu +3 more
doaj +1 more source
Molecular Medicine, 2021 Background Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (HBV)-related hepatocellular ...
Jiancheng Wang +10 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Long non-coding RNA (lncRNA) X-inactive specific transcript (Xist) is involved in apoptosis and inflammatory injury. This study aimed to assess the role of lncRNA Xist in sevoflurane-induced social and emotional impairment and neuronal apoptosis in ...
Lili Xu +7 more
doaj +1 more source
LncRNA XIST facilitates hypertrophy of ligamentum flavum by activating VEGFA-mediated autophagy through sponging miR-302b-3p. [PDF]
Biol Direct, 2023 Background Increasing evidences have shown that long non-coding RNAs (lncRNAs) display crucial regulatory roles in the occurrence and development of numerous diseases.
Cao Y, Li J, Qiu S, Ni S, Duan Y.
europepmc +2 more sources
The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE
JCI Insight, 2023 Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with a dramatic sex bias, affecting 9 times more women than men. Activation of Toll-like receptor 7 (TLR7) by self-RNA is a central pathogenic process leading to aberrant production of type I interferon (IFN) in SLE, but the specific RNA molecules that serve as ...
Jonathan D. Crawford +14 more
openaire +3 more sources
Long non-coding RNA XIST: a novel oncogene in multiple cancers
Molecular Medicine, 2021 Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple
Jun Yang +4 more
doaj +1 more source
Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]
, 2007 Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea +7 more
core +1 more source