Results 11 to 20 of about 33,716 (178)

LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA [PDF]

Archives of Endocrinology and Metabolism
Objective: This study sought to investigate the regulation of long noncoding RNA (lncRNA) XIST on the microRNA (miR)-101-3p/vascular endothelial growth factor A (VEGFA) axis in neovascularization in diabetic retinopathy (DR).
Weina Fu, Yunyan Ye, Feng Hu
doaj   +5 more sources

LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms. [PDF]

PLoS Genetics, 2018
Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor ...
Sarah Carmona, Benjamin Lin, Tristan Chou, Katti Arroyo, Sha Sun   +4 more
doaj   +5 more sources

Effect of lncRNA XIST on acute myeloid leukemia cells via miR-142-5p-PFKP axis

Hematology
Acute myeloid leukemia (AML) is the common blood cancer in hematopoietic system-related diseases and has a poor prognosis. Studies have shown that long non-coding RNAs (lncRNAs) are closely related to the pathogenesis of a variety of diseases, including ...
Zhaozhi Jiang, Tingting Liu, Youhong Wang, Jiao Li, Lusheng Guo   +4 more
exaly   +4 more sources

lncRNA XIST Interacts with Regulatory T Cells within the Tumor Microenvironment in Chronic Hepatitis B-Associated Hepatocellular Carcinoma [PDF]

Türk Patoloji Dergisi
Objective: Alterations in the expression of several long non-coding RNAs (lncRNAs) have been shown in chronic hepatitis B-associated hepatocellular carcinoma (CHB-HCC).
Burcin PEHLIVANOGLU, Anil AYSAL, Cihan AGALAR, Tufan EGELI, Mucahit OZBILGIN, Tarkan UNEK, Ilkay Tugba UNEK, Ilhan OZTOP, Safiye AKTAS, Ozgul SAGOL   +9 more
doaj   +3 more sources

Knockdown of lncRNA XIST Ameliorates IL-1β-Induced Apoptosis of HUVECs and Change of Tissue Factor Level via miR-103a-3p/HMGB1 Axis in Deep Venous Thrombosis by Regulating the ROS/NF-κB Signaling Pathway

Cardiovascular Therapeutics, 2022
Background. The effect of lncRNA X inactive-specific transcript (XIST) inducing cardiovascular diseases on deep vein thrombosis (DVT) and its mechanism has not been reported.
Guangxin Cao, Hua Zhou, Dong Wang, Lei Xu   +3 more
doaj   +2 more sources

The role of lncRNAs and XIST in oral cancer

Frontiers in Cell and Developmental Biology, 2022
Long non-coding RNA (lncRNA) plays a significant role in the pathogenesis of many human malignant tumors, including oral cancer. LncRNA can act as a gene regulator in a variety of cancers.
Huimin Liu, Dongxu Wang, Shaoning Kan, Ming Hao, Lu Chang, Pengxu Lu, Yangyang Liu, Ye Jin, Weiwei Liu, Weiwei Liu   +9 more
doaj   +3 more sources

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 [PDF]

Nature, 2014
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one X chromosome during development in
Eric S. Lander, McHugh, Colleen A, Christina Tran, Surka, Christine F., Julia Su, Christine F. Surka, Lander, Eric S, Moradian, Annie, Burghard, Christina, Amy Chow, Su, Julia, Guttman, Mitchell, Lander, Eric Steven, Lander, Eric, Tran, Christina, Mitchell Guttman, Michael J. Sweredoski, Sweredoski, Michael J., Annie Moradian, Christina Burghard, Kathrin Plath, Sonja Hess, Lander, Eric S., Pandya-Jones, Amy, Blanco, Mario, McDonel, Patrick, Chow, Amy, Colleen A. McHugh, Shishkin, Alexander A, Sweredoski, Michael J, Plath, Kathrin, Alexander A. Shishkin, Surka, Christine F, McHugh, Colleen A., Shishkin, Alexander A., Amy Pandya-Jones, Mario Blanco, Chen, Chun-Kan, Hess, Sonja, Chun-Kan Chen, Patrick McDonel   +40 more
core   +10 more sources

Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

Clinical and Translational Oncology, 2023
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties.
Masoodi, T., Dari, M. A. G., Nasrolahi, A., Ghaedrahmati, F., Uddin, S., Azizidoost, S., Radoszkiewicz, K., Farzaneh, M., Sheykhi-Sabzehpoush, M., Najafi, S., Khoshnam, S. E.   +10 more
core   +3 more sources

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome [PDF]

Science, 2013
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of ...
Engreitz, Jesse M., Kadri, Sabah, Lander, Eric S., Goren, Alon, Pandya-Jones, Amy, McDonel, Patrick, Surka, Christine, Engreitz, Jesse Michael, Plath, Kathrin, Guttman, Mitchell, Lander, Eric Steven, Shishkin, Alexander, Xing, Jeffrey, Sirokman, Klara   +13 more
core   +7 more sources

CVB3 regulates Treg cell pyroptosis through the lncRNA XIST/miR-195-5p/caspase-1 molecular axis

Immunobiology
Viral myocarditis (VMC) is characterized by severe cardiac inflammation and is a major cause of congestive heart failure and sudden cardiac death in healthy young people.
Yan Zhang, Lei Yang, Huiting Mu, Na Li, Xuejia Wang, Hualan Lei, Mingjie Pang   +6 more
doaj   +2 more sources