Results 81 to 90 of about 33,716 (178)
Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential
AGING MEDICINE, Volume 9, Issue 4, Page 416-425, August 2026.Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang +5 more
wiley +1 more source
Biomedicine & Pharmacotherapy, 2020 Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been verified as an oncogenic gene in human cancers, including nasopharyngeal carcinoma (NPC). However, the role of XIST in NPC remains to be largely uncovered, as well as its underlying mechanism.Expression of XIST, miR-148a-3p and ADAM17 was detected using qPCR and western blot ...
Jinfeng, Shi +4 more
openaire +2 more sources
Functional dissection of the Xist lncRNA conserved sequences in X-chromosome inactivation
, 2022 Tese de mestrado, Biologia Molecular e Genética, Universidade de Lisboa, Faculdade de Ciências, 2019Introduction: Due to the discrepancy in the number of X chromosomes between the sexes in many animal species, dosage compensation mechanisms have evolved ...
Gil, Cláudia Raquel Estopa
core
Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer
Proceedings of the National Academy of SciencesPlasticity, a key hallmark of cancer, enables cells to transition into different states, driving tumor heterogeneity. This cellular plasticity is associated with cancer progression, treatment resistance, and relapse. Cancer stem cells (CSCs) play a central role in this process, yet the molecular factors underlying cancer cell stemness remain poorly ...
Ikrame Naciri +11 more
openaire +4 more sources
Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.ABSTRACT Osteoporosis arises from an imbalance among osteoblast‐mediated bone formation, osteoclast‐mediated bone resorption, and osteocyte‐directed mechanosensory control, but the molecular events that connect aging, hormonal change, inflammation, and mechanical unloading to bone loss remain incompletely resolved.
Minjuan Du, Leisheng Wang
wiley +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.Schematic diagram illustrating the molecular mechanism by which lncRNA AK050834 drives vascular smooth muscle cell (VSMC) senescence. Extracellular stimuli, including D‐galactose and natural aging, induce the upregulation of AK050834. AK050834 exerts dual regulatory functions: (1) In the nucleus, it directly binds to the ATF3 promoter region to ...
Haoran Wu +9 more
wiley +1 more source
Expression Landscape and Circadian Regulation of lncRNAs in the Kidney
Acta Physiologica, Volume 242, Issue 8, August 2026.ABSTRACT Recent multi‐omics work shows that the diurnal rhythmicity of kidney function is associated with circadian oscillations in renal mRNA, protein and metabolite abundances. Yet circadian regulation of renal lncRNAs, which are emerging as important modulators of diverse (patho)physiological processes, remains largely unexplored. Here, we provide a
Leonore Wigger +4 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 2, Page 302-319, 15 July 2026.Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon +5 more
wiley +1 more source
The roles of lncRNA XIST in Cancer Chemoresistance
ExRNA, 2023 Lee Chia-I +2 more
openaire +1 more source
Association Between Serum lncRNA XIST Levels and Depressive Disorder
Long non-coding RNA (lncRNA) XIST has been implicated in the pathogenesis of depression, yet its precise role in the disorder remains inadequately understood.
Peng, Rui
core +1 more source