Results 91 to 100 of about 33,716 (178)

Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer

, 2017
Tumor progression and metastasis is the main cause of death in colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer.
Zhao-lei Zeng, Dong-liang Chen, Peng Huang, Rui-hua Xu, Dong-sheng Zhang, Zhi-zhong Pan, Feng-hua Wang, Huai-qiang Ju, Le-zong Chen, Yun-xin Lu, Yu-hong Li   +10 more
core   +1 more source

SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells [PDF]

, 2016
Long noncoding RNAs (lncRNAs) are important regulators of gene expression, but their structural features are largely unknown. We used structure-selective chemical probing to examine the structure of the Xist lncRNA in living cells and found that the RNA ...
Inoue, Kaoru, Friedersdorf, Matthew, Weeks, Kevin M., Nicholson, Cindo O., Christy, Thomas W., Keene, Jack D., Smola, Matthew J., Calabrese, J. Mauro, Lee, David M.   +8 more
core   +1 more source

Long Noncoding RNA XIST Regulates miR-137‐EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer

, 2018
We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism.
Xingxiang Liu, Dong Hua, Lin Cui
core   +1 more source

lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP

Oncology Reports, 2017
X-inactive specific transcript (XIST), one of the first found cancer-associated long non-coding RNAs (lncRNAs), is involved in the development and progression of many types of tumors. Aberrant expression of XIST has been observed in hepatocellular carcinoma, cervical, breast, ovarian and colorectal cancer.
Yongjun, Tang, Ruoxi, He, Jian, An, Pengbo, Deng, Li, Huang, Wei, Yang   +5 more
openaire   +3 more sources

NYU-BFX/lncRNA-screen: v0.1

, 2016
lncRNA ...
gongyixiao, Aristotelis Tsirigos
core   +1 more source

Absence of Salivary lncRNA-XIST Indicates High Susceptibility to Oral Cancer

, 2018
Oral cancer is one of the most common malignancies worldwide, with a two- or three-fold prevalence among men than among women. Except for lifestyle-related risk factors including smoking, drinking, and betel chewing, family history is a major determinant of risk in the absence of exposure to carcinogens.
Chung-Ji Liu, Tzong-Ming Shieh, Wen-Chen Wang, Chiu-Chu Liao, Hui-Wen Chang, Yin-Hwa Shih   +5 more
openaire   +1 more source

Discovering therapeutic possibilities for polycystic ovary syndrome by targeting XIST and its associated ceRNA network through the analysis of transcriptome data

Scientific Reports
Long non-coding RNA (lncRNA) regulates many physiological processes by acting as competitive endogenous RNA (ceRNA). The dysregulation of lncRNA X-inactive specific transcript (XIST) has been shown in various human disorders.
Elahe Berenji, Ali Valipour Motlagh, Marziyeh Fathi, Maryam Esmaeili, Tayebeh Izadi, Parsa Rezvanian, Maryam Zanjirband, Zahra Safaeinejad, Mohammad Hossein Nasr-Esfahani   +8 more
doaj   +1 more source

Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs

Molecular Cell
The mechanisms and biological roles of Polycomb repressive complex (PRC) recruitment by long noncoding RNAs (lncRNAs) remain unclear. To gain insight, we expressed two lncRNAs that recruit PRCs to multi-megabase domains, Airn and Xist, from an ectopic locus in mouse stem cells and compared effects.
Trotman, Jackson B., Abrash, Elizabeth W., Murvin, McKenzie M., Braceros, Aki K., Li, Shuang, Boyson, Samuel P., Salcido, Ryan T., Cherney, Rachel E., Bischoff, Steven R., Kaufmann, Kyle, Eberhard, Quinn E., Zhang, Zhiyue, Cowley, Dale O., Calabrese, J. Mauro   +13 more
openaire   +2 more sources

XIST and MUC1-C form an auto-regulatory pathway in driving cancer progression

Cell Death and Disease
The long non-coding RNA X-inactive specific transcript (lncRNA XIST) and MUC1 gene are dysregulated in chronic inflammation and cancer; however, there is no known interaction of their functions.
Keyi Wang, Atrayee Bhattacharya, Naoki Haratake, Tatsuaki Daimon, Ayako Nakashoji, Hiroki Ozawa, Bo Peng, Wei Li, Donald Kufe   +8 more
doaj   +1 more source

Long noncoding RNA XIST promotes cell proliferation and migration in diabetic foot ulcers through the miR-126-3p/EGFR axis

Diabetology & Metabolic Syndrome
Background The prevalence of diabetic foot ulcers (DFUs) has caused serious harm to human health. To date, a highly effective treatment is lacking. Long noncoding RNA X-inactive specific transcript (lncRNA XIST) has been the subject of mounting research ...
Wangbing Hong, Zhenfang Xiong, Xin Wang, Xincheng Liao, Mingzhuo Liu, Zhengying Jiang, Dinghong Min, Jiaqi Li, Guanghua Guo, Zhonghua Fu   +9 more
doaj   +1 more source