Results 1 to 10 of about 909,466 (193)

A Ribosomal Perspective on Neuronal Local Protein Synthesis [PDF]

Frontiers in Molecular Neuroscience, 2022
Continued mRNA translation and protein production are critical for various neuronal functions. In addition to the precise sorting of proteins from cell soma to distant locations, protein synthesis allows a dynamic remodeling of the local proteome in a ...
Sudhriti Ghosh Dastidar, Deepak Nair
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Vesicular Rps6 Released by Astrocytes in an Experimental Model of AD Regulates Local Translation and Enhances Synaptic Integrity in Neurones [PDF]

Journal of Extracellular Vesicles
In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover.
María Gamarra, Aida de la Cruz‐Gambra, Maite Blanco‐Urrejola, Esperanza González, Mikel Azkargorta, Felix Elortza, Juan Manuel Falcón‐Pérez, Jimena Baleriola   +7 more
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Tracking and measuring local protein synthesis in vivo [PDF]

Development, 2021
ABSTRACT Detecting when and how much of a protein molecule is synthesized is important for understanding cell function, but current methods either cannot be performed in vivo or have poor temporal resolution. Here, we developed a technique to detect and quantify subcellular protein synthesis events in real time in vivo.
Ibrahim Kays, Brian E. Chen
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Identifying mRNAs Residing in Myelinating Oligodendrocyte Processes as a Basis for Understanding Internode Autonomy

Life, 2023
In elaborating and maintaining myelin sheaths on multiple axons/segments, oligodendrocytes distribute translation of some proteins, including myelin basic protein (MBP), to sites of myelin sheath assembly, or MSAS.
Robert Gould, Scott Brady
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Local protein synthesis in neurons [PDF]

Current Biology, 2001
[No abstract] ; © 2001 Elsevier Science Ltd. Available online 26 November 2001.
Smith, W. Bryan, Aakalu, Girish, Schuman, Erin M.   +2 more
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A karyopherin acts in localized protein synthesis [PDF]

Cell Cycle, 2010
Multiple mechanisms are in place to regulate adequate synthesis of proteins, ranging from ways to ensure sequence fidelity, polypeptide folding and protein modification, to control of amounts and subcellular localization of the molecules. Some of these mechanisms act at the level of mRNA export and mRNA targeting.
Veenhoff, Liesbeth M., Meinema, Anne C., Poolman, Bert   +2 more
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RNA Localization and Local Translation in Glia in Neurological and Neurodegenerative Diseases: Lessons from Neurons

Cells, 2021
Cell polarity is crucial for almost every cell in our body to establish distinct structural and functional domains. Polarized cells have an asymmetrical morphology and therefore their proteins need to be asymmetrically distributed to support their ...
Maite Blanco-Urrejola, Adhara Gaminde-Blasco, María Gamarra, Aida de la Cruz, Elena Vecino, Elena Alberdi, Jimena Baleriola   +6 more
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Transcriptomes of Injured Lamprey Axon Tips: Single-Cell RNA-Seq Suggests Differential Involvement of MAPK Signaling Pathways in Axon Retraction and Regeneration after Spinal Cord Injury

Cells, 2022
Axotomy in the CNS activates retrograde signals that can trigger regeneration or cell death. Whether these outcomes use different injury signals is not known.
Li-Qing Jin, Yan Zhou, Yue-Sheng Li, Guixin Zhang, Jianli Hu, Michael E. Selzer   +5 more
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BDNF-induced local protein synthesis and synaptic plasticity [PDF]

Neuropharmacology, 2014
Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a role in the formation of certain forms of memory. The effects of BDNF in LTP are mediated by TrkB (tropomyosin-related kinase B) receptors, which are known to be coupled to
Leal, Graciano, Comprido, Diogo, Duarte, Carlos B.   +2 more
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Selective targeting of mRNA and the following protein synthesis of CaMKIIα at the long-term potentiation-induced site

Biology Open, 2020
Late-phase long-term potentiation (L-LTP) in hippocampus, thought to be the cellular basis of long-term memory, requires new protein synthesis. Neural activity enhances local protein synthesis in dendrites, which in turn mediates long-lasting synaptic ...
Itsuko Nihonmatsu, Noriaki Ohkawa, Yoshito Saitoh, Reiko Okubo-Suzuki, Kaoru Inokuchi   +4 more
doaj   +1 more source