Results 11 to 20 of about 909,585 (312)
Polysomal Localization of R17 Bacteriophage-Specific Protein Synthesis [PDF]
Journal of Virology, 1972 Synthesis of viral ribonucleic acid (RNA) polymerase, maturation protein, and coat protein in Escherichia coli infected with bacteriophage R17 occurs mainly on polysomes containing four or more ribosomes. The 30 S ribosomal subunits through trimer-size polysomes, which are associated with all
J L, Truden, R M, Franklin
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100th Anniversary of Macromolecular Science Viewpoint: Opportunities in the Physics of Sequence-Defined Polymers [PDF]
, 2020 Polymer science has been driven by ever-increasing molecular complexity, as polymer synthesis expands an already-vast palette of chemical and architectural parameter space.
Perry, Sarah L., Sing, Charles E.
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The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders
Frontiers in Molecular Biosciences, 2020 As neurons are one of the most highly polarized cells in our body, they require sophisticated cellular mechanisms to maintain protein homeostasis in their subcellular compartments such as axons and dendrites.
Maximilian Paul Thelen, Min Jeong Kye
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Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons [PDF]
Neuron, 2001 Using pharmacological approaches, several recent studies suggest that local protein synthesis is required for synaptic plasticity. Convincing demonstrations of bona fide dendritic protein synthesis in mammalian neurons are rare, however. We developed a protein synthesis reporter in which the coding sequence of green fluorescent protein is flanked by ...
Aakalu, G. +4 more
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Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons
eLife, 2019 Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this ...
Max Koppers +14 more
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Protein synthesis at synaptic sites on dendrites [PDF]
, 2001 Studies over the past 20 years have revealed that gene expression in neurons is carried out by a distributed network of translational machinery. One component of this network is localized in dendrites, where polyribosomes and associated membranous ...
Schuman, Erin M., Steward, Oswald
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Local Protein Synthesis in Axonal Growth Cones [PDF]
Cell Adhesion & Migration, 2007 While initially thought to be essentially a developmental characteristic, observed in artificial in vitro models, local protein synthesis in growth cones has been described in the adult, and more interestingly, during nerve regeneration. This emerging field is under intense investigation, revealing new functions of localized protein synthesis that ...
Saulius, Satkauskas, Dominique, Bagnard
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Axon-glia interaction and membrane traffic in myelin formation
Frontiers in Cellular Neuroscience, 2014 In vertebrate nervous systems myelination of neuronal axons has evolved to increase conduction velocity of electrical impulses with minimal space and energy requirements.
Robin eWhite, Eva-Maria eKrämer-Albers
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Frontiers in Neural Circuits, 2009 Fragile X syndrome, the most frequent form of familial mental retardation, is caused by mutation of the Fmr1 gene. Fmr1 encodes the Fragile X Mental Retardation Protein (FMRP), an mRNA binding protein regulating local, postsynaptic mRNA translation ...
Chanxia Li +3 more
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Leveraging Affinity Interactions to Prolong Drug Delivery of Protein Therapeutics
Pharmaceutics, 2022 While peptide and protein therapeutics have made tremendous advances in clinical treatments over the past few decades, they have been largely hindered by their ability to be effectively delivered to patients. While bolus parenteral injections have become
Alan B. Dogan +2 more
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