Results 1 to 10 of about 52,240 (185)
Locus Coeruleus in Non-Mammalian Vertebrates [PDF]
Brain Sciences, 2022 The locus coeruleus (LC) is a vertebrate-specific nucleus and the primary source of norepinephrine (NE) in the brain. This nucleus has conserved properties across species: highly homogeneous cell types, a small number of cells but extensive axonal ...
Sijia Wang, Zhirong Wang, Yu Mu
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Acupuncture-induced changes in locus coeruleus connectivity and memory improvement in patients with amnestic cognitive impairment [PDF]
IBRO Neuroscience ReportsBackground: An increasing number of neuroimaging studies have consistently indicated that the locus coeruleus is associated with cognitive impairment in the early stages of Alzheimer's disease, and the locus coeruleus plays a critical role in cognition ...
Liyu Hu +8 more
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Locus Coeruleus and Dopamine-Dependent Memory Consolidation [PDF]
Neural Plasticity, 2017 Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation ...
Miwako Yamasaki, Tomonori Takeuchi
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Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity [PDF]
eLifeImpairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda +6 more
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PLoS ONE, 2023 Patients with Parkinson’s disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson’s disease simultaneously
Kristy S. Hwang +4 more
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Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns
Brain Sciences, 2021 After reviewing seminal studies using optogenetics to interrogate the functional role of the locus coeruleus in behavior, we conclude that differences in firing rates and firing patterns of locus coeruleus neurons contribute to locus coeruleus nucleus ...
Carolyn W. Harley, Qi Yuan
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Pupil tracks statistical regularities: behavioral and neural implications [PDF]
Journal of Integrative Neuroscience, 2020 Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
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Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna +9 more
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Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease
Neural Regeneration Research, 2020 The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari +2 more
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PLoS Computational Biology, 2022 Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans +14 more
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