Results 1 to 10 of about 57,269 (250)

Propofol regulates arousal by enhancing inhibitory synaptic transmission of noradrenergic neurons in the locus coeruleus of adult male mice [PDF]

Scientific Reports
Locus coeruleus-noradrenergic (LC-NA) neurons have been suggested to be involved in the effects of general anesthetics. However, the contribution of LC-NA neurons during propofol anesthesia remains unknown.
Tatsuya Abe, Miyuki Kurabe, Yuka Nakamura, Mika Sasaki, Yutaka Seino, Kenta Furutani, Masaki Ueno, Hiroshi Baba   +7 more
doaj   +4 more sources

Chronic stress impairs autoinhibition in neurons of the locus coeruleus to increase asparagine endopeptidase activity [PDF]

eLife
Impairments of locus coeruleus (LC) are implicated in anxiety/depression and Alzheimer’s disease (AD). Increases in cytosolic noradrenaline (NA) concentration and monoamine oxidase A (MAO-A) activity initiate the LC impairment through production of NA ...
Hiroki Toyoda, Doyun Kim, Byeong Geon Koh, Tomomi Sano, Takashi Kanematsu, Seog Bae Oh, Youngnam Kang   +6 more
doaj   +2 more sources

In vivo detection of substantia nigra and locus coeruleus volume loss in Parkinson's disease using neuromelanin-sensitive MRI: Replication in two cohorts.

PLoS ONE, 2023
Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang, Jason Langley, Richa Tripathi, Xiaoping P Hu, Daniel E Huddleston   +4 more
doaj   +3 more sources

Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns

Brain Sciences, 2021
After reviewing seminal studies using optogenetics to interrogate the functional role of the locus coeruleus in behavior, we conclude that differences in firing rates and firing patterns of locus coeruleus neurons contribute to locus coeruleus nucleus ...
Carolyn W. Harley, Qi Yuan
doaj   +1 more source

Pupil tracks statistical regularities: behavioral and neural implications [PDF]

Journal of Integrative Neuroscience, 2020
Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
doaj   +1 more source

Age- and Sex-Dependent Changes in Locus Coeruleus Physiology and Anxiety-Like Behavior Following Acute Stressor Exposure

Frontiers in Behavioral Neuroscience, 2022
Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna, Olga Borodovitsyna, John A. Tkaczynski, John A. Tkaczynski, Claire M. Corbett, Claire M. Corbett, Jessica A. Loweth, Jessica A. Loweth, Daniel J. Chandler, Daniel J. Chandler   +9 more
doaj   +1 more source

Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease

Neural Regeneration Research, 2020
The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari, Varun Chokshi, Katharina Schmidt   +2 more
doaj   +1 more source

Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.

PLoS Computational Biology, 2022
Apathy is a debilitating feature of many neuropsychiatric diseases, that is typically described as a reduction of goal-directed behaviour. Despite its prevalence and prognostic importance, the mechanisms underlying apathy remain controversial ...
Frank H Hezemans, Noham Wolpe, Claire O'Callaghan, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe   +14 more
doaj   +1 more source

Noradrenergic signaling mediates cortical early tagging and storage of remote memory

Nature Communications, 2022
The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu   +6 more
doaj   +1 more source

Neurophysiological investigations of drug resistant epilepsy patients treated with vagus nerve stimulation to differentiate responders from non-responders [PDF]

, 2020
Background and purpose In patients treated with vagus nerve stimulation (VNS) for drug resistant epilepsy (DRE), up to a third of patients will eventually not respond to the therapy.
Boon, Paul, Bouckaert, Charlotte, Carrette, Evelien, Carrette, Sofie, Dauwe, Ine, Dewaele, Frank, Gadeyne, Stefanie, Goossens, Lutgart, Hödl, Stephanie, Mertens, Ann, Meurs, Alfred, Proesmans, Silke, Raedt, Robrecht, Vonck, Kristl   +13 more
core   +2 more sources