Results 1 to 10 of about 32,095 (238)
PLoS ONE, 2023 Patients with Parkinson's disease undergo a loss of melanized neurons in substantia nigra pars compacta and locus coeruleus. Very few studies have assessed substantia nigra pars compacta and locus coeruleus pathology in Parkinson's disease simultaneously
Kristy S Hwang +4 more
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Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns
Brain Sciences, 2021 After reviewing seminal studies using optogenetics to interrogate the functional role of the locus coeruleus in behavior, we conclude that differences in firing rates and firing patterns of locus coeruleus neurons contribute to locus coeruleus nucleus ...
Carolyn W. Harley, Qi Yuan
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Pupil tracks statistical regularities: behavioral and neural implications [PDF]
Journal of Integrative Neuroscience, 2020 Pupillary light reflex adjusts the amount of light reaching the retina. Recent work suggests that the brainstem pupillary light reflex pathway is controlled by the environment's internal models derived from higher-order temporal statistics.
Shamini Warda, Shubham Pandey
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Locus coeruleus-norepinephrine: basic functions and insights into Parkinson’s disease
Neural Regeneration Research, 2020 The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders. In this
Bilal Abdul Bari +2 more
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Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical period of development with increased sensitivity toward psychological stressors. Many psychiatric conditions emerge during adolescence and animal studies have shown that that acute stress has long-term effects on hypothalamic ...
Olga Borodovitsyna +9 more
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Music Enhances Activity in the Hypothalamus, Brainstem, and Anterior Cerebellum during Script-Driven Imagery of Affective Scenes [PDF]
Neuropsychologia 133, 107073. Epub 2019 Apr 24, 2023 Music is frequently used to establish atmosphere and to enhance/alter emotion in dramas and films. During music listening, visual imagery is a common mechanism underlying emotion induction. The present functional magnetic resonance imaging (fMRI) study examined the neural substrates of the emotional processing of music and imagined scene.
arxiv +1 more source
Noradrenergic signaling mediates cortical early tagging and storage of remote memory
Nature Communications, 2022 The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are ...
Xiaocen Fan +6 more
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Impact of locus coeruleus and its projections on memory and aging [PDF]
, 2021 Introduction: Locus coeruleus (LC) is the primary source of norepinephrine to the brain and its efferent projections innervate many brain regions, including the thalamus. LC degrades with normal aging, but not much is known regarding whether its structural connectivity evolves with age or predicts aspects of cognition.
arxiv +1 more source
Motor neuron pathology in CANVAS due to RFC1 expansions [PDF]
Brain - A Journal of Neurology , Oxford University Press (OUP),
2021, 2022 CANVAS caused by RFC1 biallelic expansions is a major cause of inherited sensory neuronopathy. Detection of RFC1 expansion is challenging and CANVAS can be associated with atypical features. We clinically and genetically characterized 50 patients, selected based on the presence of sensory neuronopathy confirmed by EMG. We screened RFC1 expansion by PCR,
arxiv +1 more source
Locus Coeruleus in Non-Mammalian Vertebrates
Brain Sciences, 2022 The locus coeruleus (LC) is a vertebrate-specific nucleus and the primary source of norepinephrine (NE) in the brain. This nucleus has conserved properties across species: highly homogeneous cell types, a small number of cells but extensive axonal ...
Sijia Wang, Zhirong Wang, Yu Mu
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