Results 101 to 110 of about 57,269 (250)

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa, Lopez-Gimenez, Juan, Milligan, Graeme   +2 more
core   +1 more source

Sleep Slow Wave‐Bistability and the Connection Between the Sleeping Brain and the Environment—Neurobiological Considerations

Journal of Sleep Research, EarlyView.
Bistability is an inherent working mode of NREM sleep. Those bistable patterns ‐ sleep slow waves, K‐complexes, and the cyclic alternating pattern (on a longer, several seconds' time‐scale) ‐ have a double function; they protect sleep and provide an interface between the brain and the environment for information‐transfer during sleep.
Péter Halász, Anna Szűcs, Carlotta Mutti, Liborio Parrino   +3 more
wiley   +1 more source

Modulating cortical excitability and cortical arousal by pupil self-regulation

Nature Communications
The brain’s arousal state (i.e., central arousal) is regulated by multiple neuromodulatory nuclei in the brainstem and significantly influences high-level cognitive processes.
Marieke Lieve Weijs, Silvia Missura, Weronika Potok-Szybińska, Marc Bächinger, Bianca Badii, Manuel Carro-Domínguez, Nicole Wenderoth, Sarah Nadine Meissner   +7 more
doaj   +1 more source

Computational modeling of spike generation in serotonergic neurons of the dorsal raphe nucleu [PDF]

, 2012
We consider here a single-compartment model of these neurons which is capable of describing many of the known features of spike generation, particularly the slow rhythmic pacemaking activity often observed in these cells in a variety of species. Included
Penington, Nicholas J., Tuckwell, Henry C.   +1 more
core  

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. [PDF]

, 2015
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed
Alvarez, Victor E, Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dams-O'Connor, Kristen, Dickson, Dennis W, Folkerth, Rebecca D, Gordon, Wayne A, Keene, C Dirk, Litvan, Irene, McKee, Ann C, Perl, Daniel P, Stein, Thor D, Stewart, William, TBI/CTE group, Tripodis, Yorghos, Vonsattel, Jean-Paul   +16 more
core   +3 more sources

Refined Division of Sleep Stages in the Mouse Based on Distributed Deep Electrodes and Underlying Infra‐Slow Oscillation

Journal of Sleep Research, EarlyView.
ABSTRACT The mouse sleep is mostly recorded with only epidural electrodes and divided simply into NREM and REM stages. With the help of distributed intracerebral triplet electrodes, we searched for possible new electrophysiological signatures to characterise more specific sleep substages within the timeframe of seconds to tens of minutes.
Nanxiang Jin, Sara Häkli, Keerthana Malathi, Hennariikka Koivisto, Theodor Boc, Jonas Schimmel, Eric Castell‐Caubet, Irina Gureviciene, Heikki Tanila   +8 more
wiley   +1 more source

Electrophysiological correlates of attention in the locus coeruleus–prelimbic cortex circuit during the rodent continuous performance test [PDF]

, 2023
Henry L. Hallock, Suhaas S. Adiraju, Jorge Miranda‐Barrientos, Jessica M. McInerney, Seyun Oh, Adrienne C. DeBrosse, Ye Li, Gregory V. Carr, Keri Martinowich   +8 more
openalex   +1 more source

The hypoxic ventilatory response and arousal burden predict the magnitude of ventilatory long‐term facilitation in humans with obstructive sleep apnoea

Experimental Physiology, EarlyView.
Abstract The magnitude of progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) are two forms of respiratory plasticity that are enhanced in some humans with obstructive sleep apnoea (OSA). This response might be linked to repeated nocturnal exposure to intermittent hypoxia or other traits connected to OSA.
Jason H. Mateika, Danny Hammo, Dylan M. Kissane, Ali Azarbarzin   +3 more
wiley   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Transcranial photobiomodulation with near‐infrared laser induces analgesia in rats

The Journal of Physiology, EarlyView.
Abstract figure legend Transcranial photobiomodulation (tPBM) with a 1064 nm laser alleviated pain. Local field potential (LFP) intensity markedly increased following formalin injection, indicating nociceptive activation. However, after tPBM, this formalin‐induced LFP hyperactivation was diminished. Meanwhile, tPBM preserved brain connectivity that was
Zhen Wang, Anqi Wu, Hanli Liu, Yuan Bo Peng   +3 more
wiley   +1 more source