Results 141 to 150 of about 32,095 (238)
The Journal of Physiology, EarlyView.Abstract figure legend We investigated electrophysiological changes in lateral habenula (LHb) neurons induced by chronic social defeat stress in mice. LHb neurons exhibited short (<400 ms) rebound depolarizing potentials (short‐RDPs) or long‐RDPs (order of seconds) (long‐RDPs) after the offset of hyperpolarization. The incidence of long‐RDP neurons was
Kenji Yamaoka +12 more
wiley +1 more source
Robust enkephalin innervation of the locus coeruleus from the rostral medulla [PDF]
, 1992 Guy Drolet +2 more
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Quantitative Biology, Volume 13, Issue 3, September 2025.Abstract Alzheimer’s disease (AD) is a common neurodegenerative disorder nowadays. Amyloid‐beta (Aβ) and tau proteins are among the main contributors to the AD progression. In AD, Aβ proteins clump together to form plaques and disrupt cell functions.
Swadesh Pal, Roderick Melnik
wiley +1 more source
Locus coeruleus stimulation by corticotropin-releasing hormone suppresses in vitro cellular immune responses [PDF]
, 1994 Stefanie Rassnick, AF Sved, B. S. Rabin
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α‐Synuclein in Parkinson's Disease: From Bench to Bedside
Medicinal Research Reviews, Volume 45, Issue 3, Page 909-946, May 2025.ABSTRACT α‐Synuclein (α‐syn), a pathological hallmark of PD, is emerging as a bridging element at the crossroads between neuro/immune‐inflammatory responses and neurodegeneration in PD. Several evidence show that pathological α‐syn accumulates in neuronal and non‐neuronal cells (i.e., neurons, microglia, macrophages, skin cells, and intestinal cells ...
Gabriele Bellini +8 more
wiley +1 more source
The Awakening of the Newborn Human Infant and the Emergence of Consciousness
Acta Paediatrica, Volume 114, Issue 5, Page 823-828, May 2025.ABSTRACT Consciousness develops gradually in the womb and after birth, rather than being an all or none phenomenon. A newborn infant is aroused and wakes up at birth, due to the enormous sensory stimulation and stress that it undergoes during the transition from an aquatic environment to air. Its first breaths activate the locus coeruleus, as indicated
Hugo Lagercrantz
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Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway
Advanced Science, Volume 12, Issue 15, April 17, 2025.This study have elucidated the brain‐targeted delivery pathways and transport mechanisms of nanoodors by various technical means and found that the olfactory pathway is main one. Nanoodors can rapidly deliver drugs to the central nervous system via olfactory pathway and will hopefully solve the delivery challenges for various types of central nervous ...
Wei Zhang +8 more
wiley +1 more source
Annals of Neurology, Volume 97, Issue 4, Page 741-752, April 2025.Objective Parkinson's disease (PD) resting tremor is thought to be initiated in the basal ganglia and amplified in the cerebello‐thalamo‐cortical circuit. Because stress worsens tremor, the noradrenergic system may play a role in amplifying tremor. We tested if and how propranolol, a non‐selective beta‐adrenergic receptor antagonist, reduces PD tremor ...
Anouk van der Heide +8 more
wiley +1 more source
Archiv der Pharmazie, Volume 358, Issue 4, April 2025.Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive onset of symptoms, including memory loss, accompanied by other neurological impairments. This progression is attributed to the deterioration of neuronal connections and a decrease in neurotransmission.
Alice Wang +3 more
wiley +1 more source