Results 31 to 40 of about 32,095 (238)

Integration of Simultaneous Resting-State Electroencephalography, Functional Magnetic Resonance Imaging, and Eye-Tracker Methods to Determine and Verify Electroencephalography Vigilance Measure [PDF]

Brain Connectivity 10.10 (2020): 535-546, 2019
Background/Introduction: Concurrent electroencephalography and resting-state functional magnetic resonance imaging (rsfMRI) have been widely used for studying the (presumably) awake and alert human brain with high temporal/spatial resolution. Although rsfMRI scans are typically collected while individuals are instructed to focus their eyes on a fixated
arxiv   +1 more source

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Communications Biology, 2023
Chemogenetic and optogenetic profiling in a rat model of acute pain-related unpleasantness suggests that colorectal distention-induced place aversion is mediated by locus coeruleus noradrenergic signalling to astrocytes in anterior cingulate cortex.
Zafar Iqbal, Zhuogui Lei, Aruna S. Ramkrishnan, Shu Liu, Mahadi Hasan, Mastura Akter, Yuk Yan Lam, Ying Li   +7 more
doaj   +1 more source

Hypocretin/orexin influences chronic sleep disruption injury in the hippocampus

Frontiers in Aging Neuroscience, 2022
Chronic sleep disruption is a risk factor for Alzheimer’s disease (AD), yet mechanisms by which sleep disturbances might promote or exacerbate AD are not understood.
Henry Nick, Polina Fenik, Yan Zhu, Sigrid Veasey   +3 more
doaj   +1 more source

Characterization of Age-related Microstructural Changes in Locus Coeruleus and Substantia Nigra Pars Compacta [PDF]

, 2019
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young ...
arxiv   +1 more source

Noradrenergic neuromodulation of nonlinear bursting neurons controls critical dynamics [PDF]

arXiv, 2021
In order to remain adaptable to a dynamic environment, neural activity must be simultaneously both sensitive and stable. To solve this problem, the brain has been hypothesised to sit near a critical boundary. Yet, precisely how criticality and these opposing information processing modes are implemented in the brain remains elusive. A potential solution
arxiv  

Locus coeruleus features are linked to vagus nerve stimulation response in drug-resistant epilepsy

Frontiers in Neuroscience
The locus coeruleus–norepinephrine system is thought to be involved in the clinical effects of vagus nerve stimulation. This system is known to prevent seizure development and induce long-term plastic changes, particularly with the release of ...
Alexandre Berger, Alexandre Berger, Alexandre Berger, Elise Beckers, Elise Beckers, Vincent Joris, Vincent Joris, Gaëtan Duchêne, Venethia Danthine, Nicolas Delinte, Nicolas Delinte, Inci Cakiroglu, Siya Sherif, Enrique Ignacio Germany Morrison, Andres Torres Sánchez, Andres Torres Sánchez, Benoit Macq, Laurence Dricot, Gilles Vandewalle, Riëm El Tahry, Riëm El Tahry   +20 more
doaj   +1 more source

Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia

European Journal of Neurology, Volume 30, Issue 1, Page 32-46, January 2023., 2023
The Magnetic Resonance Imaging features of Locus Coeruleus (LC) at baseline in Mild Cognitive Impairment subjects converting to dementia at follow‐up (cMCI) differ from those of non‐converting ones (ncMCI). This is specifically related to rostral LC and is more evident in the left LC.
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi   +20 more
wiley   +1 more source

Selective WGA uptake in the hippocampus from the locus coeruleus of DBH-WGA transgenic mice

Frontiers in Behavioral Neuroscience, 2012
We generated transgenic mice in which a transsynaptic tracer, wheat germ agglutinin (WGA), was specifically expressed in the locus coeruleus neurons under the control of the dopamine-β-hydroxylase gene promoter. WGA protein was produced in more than 95%
Susan G eWalling, Robert A.M. Brown, Nobuhiko eMIYASAKA, Yoshihiro eYoshihara, Carolyn W Harley   +4 more
doaj   +1 more source

The Locus Coeruleus: Anatomy, Physiology, and Stress-Related Neuropsychiatric Disorders. [PDF]

Eur J Neurosci
Repeated and chronic exposure to stressors may activate the locus coeruleus–norepinephrine (LC‐NE) system. Depression and post‐traumatic stress disorders precipitated by a stressful event are associated with the hypersecretion of the corticotropin‐releasing factor (CRF) leading to elevated CRF levels in the brain (green arrows pointed up).
Reyes BAS.
europepmc   +2 more sources

Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profiles

Frontiers in Molecular Biosciences, 2023
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists. This
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford   +5 more
doaj   +1 more source