Results 61 to 70 of about 57,269 (250)

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Increased opioid dependence in a mouse model of panic disorder

Frontiers in Behavioral Neuroscience, 2010
Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high affinity receptor for neurotrophin-3, is a key molecule involved in panic disorder and opiate ...
Xavier Gallego, Patricia Murtra, Patricia Murtra, Teresa Zamalloa, Josep Maria Canals, Joseba Pineda, Alejandro Amador-Arjona, Rafael Maldonado, Mara Dierssen   +8 more
doaj   +1 more source

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography [PDF]

, 2012
Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT).
Baldwin, Baldwin, Chang, Ding, Gandelman, Grandoso, Jobson, Jobson, Jobson, Kanegawa, Kiyono, Kung, Lakshmi, McConathy, Schou, Schou, Schou, Seibyl, Seneca, Smith, Stoddart, Tamagnan, Tavares, Tavares, Tejani-Butt, Zeng, Zoghbi   +26 more
core   +1 more source

A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade, Pierre‐Louis Bazin, Evgeniya Kirilina, Kerrin Pine, Andreas Herrler, Ronald L. A. W. Bleijs, J. Max Kros, Lysanne Groenewegen, Sanne M. M. Vermorgen, Laura E. Jonkman, Dick F. Swaab, Rawien Balesar, Nikolaus Weiskopf, Birte U. Forstmann   +13 more
wiley   +1 more source

Parkinson's disease dementia: a neural networks perspective. [PDF]

, 2015
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core   +1 more source

3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x‐ray phase‐contrast tomography

Brain Pathology, EarlyView.
x‐ray phase‐contrast tomography enabled three‐dimensional, label‐free visualization and quantification of protein aggregates in neurodegenerative diseases with isotropic submicrometer resolution. The study revealed distinct electron density patterns in Lewy bodies, Hirano bodies, granulovacuolar degeneration, and amyloid plaques, highlighting their ...
Jonas Franz, Jakob Reichmann, Marina Eckermann, Thea Würfel, Artur Groh, Syed Fatima Qadri, Katja Schulz, Brit Mollenhauer, Christine Stadelmann, Tim Salditt   +9 more
wiley   +1 more source

The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep [PDF]

, 2016
During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge.
A Caraty, A Caraty, A Chanvallon, A Chanvallon, AC Gore, AE Herbison, AL Goodman, AM Etgen, Audrey Chanvallon, C Fabre-Nys, C Fabre-Nys, C Fabre-Nys, C Fabre-Nys, CA Barraclough, CE Adams, CE Adams, CH Conaway, CH Wu, CJ Scott, Claude Fabre-Nys, CM Oldham, CS Corker, DE Wildt, DE Wright, DF Hardy, Didier Lomet, DR Lindsay, DT Baird, DT Pearce, E Elias, FJ Karsch, FJ Karsch, GB Martin, GW Montgomery, H Gelez, HG Spies, IJ Clarke, J Bakker, JA Banks, JA Rawson, Joëlle Dupont, JP Signoret, JP Signoret, JP Signoret, JR Day, K Brown-Grant, K Maeda, L Dufy-Barbe, L Xia, Lionel Lardic, M Acosta-Martinez, MJ Baum, MJ Gibson, MS Smith, MX Zarrow, NP Evans, OR Dyrmundsson, P Mauleon, P Richard, Peter J. Hansen, Q Li, R Papay, R Ungerfeld, RD Randel, RE Szawka, Rex J. Scaramuzzi, RJ Scaramuzzi, RL Goodman, RL Goodman, RL Goodman, RL Goodman, RL Hauger, S Ben Saïd, S Yamada, SM Moenter, SP Yang, SP Yang, SP Yang, SR Milligan, SR Milligan, SR Wersinger, Stéphanie Martinet, VD Ramirez, W Jöchle, Y Tillet, Y Tillet   +85 more
core   +9 more sources

Repetitive Transcranial Electrical Stimulation Induces Quantified Changes in Resting Cerebral Perfusion Measured from Arterial Spin Labeling

Neural Plasticity, 2018
The use of transcranial electrical stimulation (TES) as a method to augment neural activity has increased in popularity in the last decade and a half. The specific application of TES to the left prefrontal cortex has been shown to produce broad cognitive
Matthew S. Sherwood, Aaron T. Madaris, Casserly R. Mullenger, R. Andy McKinley   +3 more
doaj   +1 more source

New approaches for the quantification and targeting of noradrenergic dysfunction in Alzheimer's disease

Annals of Clinical and Translational Neurology, 2022
There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that produces and releases noradrenaline, prior to involvement of cortical brain ...
Michael David, Paresh A. Malhotra
doaj   +1 more source