Results 81 to 90 of about 57,269 (250)
Insights into the role of noradrenaline in effortful decisions.
PLoS Biology, 2022 To maintain homeostasis, our brain tracks the effort exerted during decision-making. A new study in PLOS Biology shows that the activity of noradrenergic neurons in the locus coeruleus (LC) reflects the effort exerted to face cognitive or physical ...
Kristin Kaduk, Fadila Hadj-Bouziane
doaj +1 more source
The FEBS Journal, EarlyView.Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua +2 more
wiley +1 more source
Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder. [PDF]
, 2006 The DSM-III, DSM-IV, DSM-IV-TR and ICD-10 have judiciously minimized discussion of etiologies to distance clinical psychiatry from Freudian psychoanalysis.
Bracha, Dr. H. Stefan
core +1 more source
Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1
The FEBS Journal, EarlyView.PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio +12 more
wiley +1 more source
Locus Coeruleus and Dopamine-Dependent Memory Consolidation
Neural Plasticity, 2017 Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation ...
Miwako Yamasaki, Tomonori Takeuchi
doaj +1 more source
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. [PDF]
, 2011 Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD).
Akil, H +9 more
core
Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]
, 2018 IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat +7 more
core +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary The world‐wide prevalence of insomnia disorder reaches up to 10% of the adult population. Women are more often afflicted than men, and insomnia disorder is a risk factor for somatic and mental illness, especially depression and anxiety disorders.
Dieter Riemann +13 more
wiley +1 more source
Nature Communications, 2020 Alterations of locus coeruleus signal intensity have been associated with functional changes in health and disease. Here, the authors tested a pre-registered hypothesis on a large number of subjects as part of the Cam-CAN consortium.
Kathy Y. Liu +8 more
doaj +1 more source
The Locus Ceruleus in PTSD [PDF]
, 2009 NO ABSTRACT: This is 750 word encyclopedia ...
Bracha, Dr. H. Stefan +4 more
core