Results 81 to 90 of about 32,095 (238)

Analysis of Interactions Between Pyomelanin and the Extracellular Matrix in an Ex Vivo Turkey Tendon Model

open access: yesChemistryOpen, EarlyView.
Polymerization of homogentisic acid in the presence of extracellular matrix (ECM) components (an ex vivo turkey tendon model) yields simplified versions of biologically generated melanins in the ECM, facilitating studies of melanin–ECM interactions. A variety of techniques (X‐ray diffraction, microscopy, and spectroscopy) were employed to understand ...
Rebecca F. Shepherd   +11 more
wiley   +1 more source

Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia

open access: yesNature Communications, 2019
Depression and transient ischaemic attacks are tightly regulated but the neural circuits underlying depression-modulated ischaemic injury are not known.
Qian Zhang   +10 more
doaj   +1 more source

Advancing Post‐Stroke Rehabilitation: Emerging and Current Neuromodulation Approaches and Integration of Artificial Intelligence‐Driven Closed‐Loop Systems

open access: yesSensory Neuroscience, EarlyView.
AI‐Driven Neurostimulation for Post‐Stroke Rehabilitation: Leveraging Vagus Nerve Stimulation, Deep Brain Stimulation, and Brain‐Computer Interfaces in Closed‐Loop Systems to Enhance Neuroplasticity, Precision, and Treatment Automation. ABSTRACT Chronic stroke represents a significant global health burden, requiring innovative rehabilitation strategies
Tiago Cunha Reis, Ana Machado
wiley   +1 more source

The augmented base locus of real divisors over arbitrary fields [PDF]

open access: yesarXiv, 2013
We show that the augmented base locus coincides with the exceptional locus (i.e. null locus) for any nef $\mathbb{R}$-Cartier divisor on any scheme projective over a field (of any characteristic). Next we prove a semi-ampleness criterion in terms of the augmented base locus generalizing a result of Keel.
arxiv  

Integrating Spatially‐Resolved Transcriptomics Data Across Tissues and Individuals: Challenges and Opportunities

open access: yesSmall Methods, EarlyView.
Advances in spatially‐resolved transcriptomics (SRT) technologies have led to increased data generation to create large‐scale spatial atlases and enable population‐level investigation, integrating SRT data across multiple tissues, individuals, species, or phenotypes.
Boyi Guo   +6 more
wiley   +1 more source

Symptomatic narcolepsy in a dog with functional pituitary gland macroadenoma

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract Symptomatic narcolepsy in dogs has been rarely reported. A 7‐year‐old, female, neutered Greek harehound presented with chronic progressive lethargy, dysphonia, episodes of flaccid paralysis of all limbs following excitement or eating, as well as pinnae and tail alopecia, hyperpigmentation and ‘rat tail’.
Christina Koufaki   +4 more
wiley   +1 more source

Foxo1 regulates Dbh expression and the activity of the sympathetic nervous system in vivo

open access: yesMolecular Metabolism, 2014
The transcription factor FoxO1 regulates multiple physiological processes. Here, we show that FoxO1 is highly expressed in neurons of the locus coeruleus and of various sympathetic ganglions, but not in the adrenal medulla.
Daisuke Kajimura   +3 more
doaj   +1 more source

A codimension 2 component of the Gieseker-Petri locus [PDF]

open access: yesarXiv, 2020
We show that the Brill-Noether locus M^3_{18,16} is an irreducible component of the Gieseker-Petri locus in genus 18 having codimension 2 in the moduli space of curves. This result disproves a conjecture predicting that the Gieseker-Petri locus is always divisorial.
arxiv  

The class of the bielliptic locus in genus 3 [PDF]

open access: yesarXiv, 2012
Let the bielliptic locus be the closure in the moduli space of stable curves of the locus of smooth curves that are double covers of genus 1 curves. In this paper we compute the class of the bielliptic locus in \bar{M}_3 in terms of a standard basis of the rational Chow group of codimension-2 classes in the moduli space. Our method is to test the class
arxiv  

In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

open access: yesNature Communications, 2018
Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.
Hiroshi Yamaguchi   +3 more
doaj   +1 more source

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