Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12 [PDF]
BMC Genetics, 2004 Background Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic and genetic heterogeneity complicate the analysis of genome-wide
Weeks Daniel E +10 more
doaj +4 more sources
The power and robustness of maximum LOD score statistics. [PDF]
Ann Hum Genet, 2008 SummaryThe maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported.
Yoo YJ, Mendell NR.
europepmc +4 more sources
Monitoring of BNP cardiac biomarker with major emphasis on biosensing methods: A review
Sensors International, 2021 Heart failure (HF) is a prominent disease becomes a crucial cause of morbidity and mortality. It is a severe condition in which the heart is incapable to supply adequate blood to the patient's body. More than 26 million people globally exist with HF.
Twinkle Dahiya +5 more
doaj +1 more source
Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families. [PDF]
PLoS ONE, 2012 We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software.
Ary Gadelha +8 more
doaj +1 more source
Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy
Kidney International Reports, 2021 Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis.
Mallory L. Downie +14 more
doaj +1 more source
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. [PDF]
PLoS ONE, 2010 Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the ...
Steven E Boyden, Louis M Kunkel
doaj +1 more source
Differences in Odor Identification in Early-Onset and Late-Onset Depression
Brain Sciences, 2022 (1) Background: Odor identification (OI) dysfunction is a potential predictor of developing dementia in late life depression (LLD). However, it is not clear whether patients with early onset depression (EOD) and late onset depression (LOD) may exhibit ...
Meiling Liu +12 more
doaj +1 more source
Identification of quantitative trait loci controlling root and shoot traits associated with drought tolerance in a lentil (Lens culinaris Medik.) recombinant inbred line population [PDF]
, 2016 Drought is one of the major abiotic stresses limiting lentil productivity in rainfed production systems. Specific rooting patterns can be associated with drought avoidance mechanisms that can be used in lentil breeding programs.
Coyne, Clarice J +8 more
core +5 more sources
BMC Medical Genetics, 2008 Background In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV ...
de Simone Giovanni +10 more
doaj +1 more source
Kufor-Rakeb syndrome, pallido-pyramidal degeneration with supranuclear upgaze paresis and dementia, maps to 1p36 [PDF]
, 2001 Kufor-Rakeb syndrome is an autosomal recessive nigro-striatal-pallidal-pyramidal neurodegeneration. The onset is in the teenage years with clinical features of Parkinson’s disease plus spasticity, supranuclear upgaze paresis, and dementia.
Al-Din, A. +7 more
core +2 more sources