Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia
BMC Medical Genetics, 2008 Background The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS).
Frongia Paola +39 more
doaj +1 more source
Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. [PDF]
PLoS ONE, 2016 BACKGROUND:This retrospective, multicenter study aimed to reveal risk predictors for mortality in the intensive care unit (ICU) as well as survival after ICU discharge in patients with acute myeloid leukemia (AML) requiring treatment in the ICU.
Michele Pohlen +22 more
doaj +1 more source
Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis. [PDF]
, 2013 BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in ...
Baldassarre, Damiano +22 more
core +1 more source
Computing expectation values for RNA motifs using discrete convolutions
BMC Bioinformatics, 2005 Background Computational biologists use Expectation values (E-values) to estimate the number of solutions that can be expected by chance during a database scan.
Fontaine Jean-Fred +3 more
doaj +1 more source
BMC Medical Genetics, 2006 Background Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic ...
Ellison R Curtis +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 Background: Modular organization reflects the activity patterns of our brain. Different disease states may lead to different activity patterns and clinical features.
Naikeng Mai +8 more
doaj +1 more source
A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits. [PDF]
PLoS ONE, 2011 As schizophrenia is genetically and phenotypically heterogeneous, targeting genetically informative phenotypes may help identify greater linkage signals.
Yin-Ju Lien +6 more
doaj +1 more source
A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder [PDF]
, 2005 Homozygosity mapping is a very powerful method for finding rare recessive disease genes in monogenic disorders and may also be useful for locating risk genes in complex disorders, late onset disorders where parents often are not available, and for rare ...
American Psychiatric Association +21 more
core +1 more source
Aquatic Biology, 2014 Based on the parentage identification results using 4 polymorphic short sequence repeats (SSRs) with both parents known, we assessed the accuracy of parentage identification for a single known parent using the same 4 SSRs and 4 other additional SSRs for ...
K Zhang, W Wang, J Kong, K Luo, X Jin
doaj +1 more source
A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. [PDF]
, 2015 The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions.
Andersen, Erik C +7 more
core +2 more sources