Results 251 to 260 of about 72,001 (287)

Lod Score Curves for Phase-Unknown Matings

Human Heredity, 1996
For a phase-unknown nuclear family, we show that the likelihood and lod score are unimodal, and we describe conditions under which the maximum occurs at recombination fraction theta = 0, theta = 1/2, and 0 < theta < 1/2. These simply stated necessary and sufficient conditions seem to have escaped the notice of previous statistical geneticists.
T, Hulbert-Shearon, M, Boehnke, K, Lange
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Lods, wrods, and mods: The interpretation of lod scores calculated under different models

Genetic Epidemiology, 1994
AbstractIn this paper we examine the relationships among classical lod scores, “wrod” scores (lod scores calculated under the wrong genetic model), and “mod” scores (lod scores maximized over genetic model parameters). We compare the behavior of these scores when the state of nature is linkage to their behavior when the state of nature is no linkage ...
S E, Hodge, R C, Elston
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Distribution of lod Scores in Oligogenic Linkage Analysis

Genetic Epidemiology, 2001
In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effect of the ith quantitative trait locus. Using quantitative trait Q1 from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oli‐gogenic linkage ...
J T, Williams, K E, North, L J, Martin, A G, Comuzzie, H H, Göring, J, Blangero   +5 more
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Posterior probability of linkage and maximal lod score

Annals of Human Genetics, 1995
SummaryTo detect linkage between a trait and a marker, Morton (1955) proposed to calculate the lod score z(θ1) at a given value θ1 of the recombination fraction. If z(θ1) reaches +3 then linkage is concluded. However, in practice, lod scores are calculated for different values of the recombination fraction between 0 and 0·5 and the test is based on the
E, Génin, M, Martinez, F, Clerget-Darpoux   +2 more
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Effects of Misspecifying Genetic Parameters in Lod Score Analysis

Biometrics, 1986
The lod score method is widely used to test linkage and to estimate the recombination fraction between a disease locus and a marker locus. The parameters (gene frequency, penetrance, and degree of dominance) are assumed to be known at each locus. This condition may not be fulfilled at the disease locus.
F, Clerget-Darpoux, C, Bonaïti-Pellié, J, Hochez   +2 more
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MCMC Multilocus Lod Scores: Application of a New Approach

Human Heredity, 2005
On extended pedigrees with extensive missing data, the calculation of multilocus likelihoods for linkage analysis is often beyond the computational bounds of exact methods. Growing interest therefore surrounds the implementation of Monte Carlo estimation methods.
Andrew W, George, Ellen M, Wijsman, Elizabeth A, Thompson   +2 more
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Robust LOD scores for variance component-based linkage analysis

Genetic Epidemiology, 2000
The variance component method is now widely used for linkage analysis of quantitative traits. Although this approach offers many advantages, the importance of the underlying assumption of multivariate normality of the trait distribution within pedigrees has not been studied extensively.
J, Blangero, J T, Williams, L, Almasy
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The lod score method.

Advances in genetics, 2001
The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage.
J P, Rice, N L, Saccone, J, Corbett
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